78759-37-2Relevant academic research and scientific papers
New Synthesis of β-Lactams Based on Nitrone Cycloaddition to Nitroalkenes
Padwa, Albert,Koehler, Konrad F.,Rodriguez, Augusto
, p. 282 - 288 (2007/10/02)
Heating a sample of the major 5-nitro-substituted isoxazolidine isomer obtained from the reaction of a C-phenyl-N-alkylnitrone with trans-1-cyano-2-nitroethylene in methanol resulted in ring contraction and formation of 4-phenyl-3-cyano-N-alkyl-2-azetidin
NEW APPLICATIONS OF DIPOLAR CYCLOADDITION CHEMISTRY TOWARD THE SYNTHESIS OF HETEROCYCLES
Padwa, Albert,Chen, Yon-Yih,Koehler, Konrad F.,Tomas, Miguel
, p. 811 - 818 (2007/10/02)
A new method for the preparation of β-lactams has been developed.The protocol involves 1,3-dipolar cycloaddition of nitrones with nitro substituted alkenes followed by a subsequent reorganization of the resulting 5-nitroisoxazolidine isomer.The utilizatio
