787640-34-0

Usage

Ester derivative

1,2-pyrrolidinedicarboxylic acid
The compound is derived from 1,2-pyrrolidinedicarboxylic acid, which is a four-carbon cyclic amino acid.

Stereocenters

2R and 4R positions
The compound has two chiral centers, which are responsible for its stereochemistry and optical activity.

Chiral building block

Organic synthesis
It is used as a chiral building block in the synthesis of various organic compounds, particularly in the pharmaceutical industry.

Reagent

Chemical reactions
The compound serves as a reagent in various chemical reactions, facilitating the formation of new bonds and structures.

Pharmaceutical industry

Drug production
It is utilized in the pharmaceutical industry for the production of various drug compounds, contributing to the development of new medications.

Development and synthesis

New pharmaceutical drugs and compounds
The compound plays a crucial role in the development and synthesis of new pharmaceutical drugs and compounds, potentially leading to novel treatments and therapies.

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 444313-67-1 (1R,4R)-5-acetyl-2-oxa-5-azabicyclo[2.2.1]heptan-3-one 
• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 
• 51-35-4 4R-4-hydroxyproline 
• 36901-86-7 cis-hydroxy-D-proline 
• 501-53-1 benzyl chloroformate 
• 2584-71-6 cis-hydroxy-D-proline 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 

Downstream Products

• 787640-35-1 (2R,4R)-benzyl 4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 787640-36-2 (2R,4R)-benzyl 4-(tert-butyldimethylsilyloxy)-2-((methylsulfonyloxy)methyl)pyrrolidine-1-carboxylate 
• 787640-37-3 (1R,4R)-benzyl 2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate 
• 661470-56-0 (1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1194056-54-6 (2R,4R)-benzyl-4-(tert-butyldimethylsilyloxy)-2-formylpyrrolidine-1-carboxylate 
• 1610034-26-8 (2R,4R)-1-benzyl 2-methyl 4-isopropoxypyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF

The present invention relates to phenyl amino pyrimidine bicyclic compounds formula (I) which are inhibitors of protein kinases including JAK kinases. In particular the compounds are active against JAK1, JAK2, JAK3 and TYK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

ANTIBACTERIAL FLUOROQUINOLONE ANALOGS

Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity

The present invention is directed to compounds of the formula I: Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

HETEROCYCLIC CYCLOPENTYL TETRAHYDROISOQUINOLINE AND TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.