787640-35-1

Usage

General Description

The chemical "1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(hydroxymethyl)-, phenylmethyl ester, (2R,4R)-" is a phenylmethyl ester derived from 1-pyrrolidinecarboxylic acid and 2-hydroxymethyl-4-[(1,1-dimethylethyl)dimethylsilyl]oxy. It has a molecular formula of C21H35NO5Si and a molecular weight of 413.600 g/mol. This chemical belongs to the class of organic compounds known as esters, which are formed by the bonding of a carbonyl group to two alkyl or aryl groups. "1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(hydroxymethyl)-, phenylmethyl ester, (2R,4R)-" is a chiral compound with 2 stereocenters and an (R,R) configuration, and its precise uses and applications in various fields are yet to be fully explored.

Upstream product

• 36901-86-7 cis-hydroxy-D-proline 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 501-53-1 benzyl chloroformate 
• 2584-71-6 cis-hydroxy-D-proline 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 
• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 444313-67-1 (1R,4R)-5-acetyl-2-oxa-5-azabicyclo[2.2.1]heptan-3-one 
• 1004529-93-4 (2R,4R)-2-ethoxycarbonyl-4-[(tert-butyl)dimethylsilyloxy]-N-(benzyloxycarbonyl)pyrrolidine 
• 787640-34-0 (2R,4R)-1-benzyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)pyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1194056-54-6 (2R,4R)-benzyl-4-(tert-butyldimethylsilyloxy)-2-formylpyrrolidine-1-carboxylate 
• 1269622-75-4 (2R,4R)-2-azidomethyl-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-76-5 (2R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-2-(4-pyridin-3-yl-[1,2,3]triazol-1-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 787640-37-3 (1R,4R)-benzyl 2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate 
• 661470-56-0 (1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF

The present invention relates to phenyl amino pyrimidine bicyclic compounds formula (I) which are inhibitors of protein kinases including JAK kinases. In particular the compounds are active against JAK1, JAK2, JAK3 and TYK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

ANTIBACTERIAL FLUOROQUINOLONE ANALOGS

Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

RNA-selective cross-pairing of backbone-extended pyrrolidine-amide oligonucleotide mimics (bePOMs)

Pyrrolidine-amide oligonucleotide mimics (POMs) can cross-pair strongly with complementary parallel and antiparallel DNA and RNA targets in a sequence-specific fashion. As a result POMs have significant potential for applications including in vivo gene silencing, diagnostics and bioanalysis. To further modulate the DNA- and RNA-recognition properties and fine-tune the physiochemical properties of POMs for nucleic acid targeting, backbone-extended pyrrolidine-amide oligonucleotide mimics (bePOM I and II) were introduced. The bePOMs differ from the original POMs through the insertion of an additional methylene group into the backbone units, which increases the flexibility of the oligomers. bePOM I and II oligomers were synthesised using solid-phase peptide chemistry. Interestingly, UV thermal denaturation and circular dichroism studies reveals bePOM I and II can hybridise with complementary RNA, but not DNA. The Royal Society of Chemistry 2008.

Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity

The present invention is directed to compounds of the formula I: Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

HETEROCYCLIC CYCLOPENTYL TETRAHYDROISOQUINOLINE AND TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.