78766-51-5

Basic information

• Product Name: 1-(4-methylphenyl)-1H-benzo[d][1,2,3]triazole
• Synonyms: 1-(4-methylphenyl)-1H-benzo[d][1,2,3]triazole
• CAS NO: 78766-51-5
• Molecular Weight: 209.25
• Mol File: 78766-51-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)-1H-benzo[d][1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-1H-benzo[d][1,2,3]triazole(78766-51-5)
• EPA Substance Registry System: 1-(4-methylphenyl)-1H-benzo[d][1,2,3]triazole(78766-51-5)

Safety Data

• Hazardous Substances Data: 78766-51-5(Hazardous Substances Data)

Upstream product

• 91806-09-6 N¹-(p-tolyl)benzene-1,2-diamine 
• 52753-44-3 (2-nitrophenyl)-p-tolylamine 
• 95-14-7 1,2,3-Benzotriazole 
• 75-09-2 dichloromethane 
• 3076-56-0 p-tolyllead triacetate 
• 624-31-7 4-tolyl iodide 
• 240497-09-0 C₁₃H₁₂IN₃ 
• 106-49-0 p-toluidine 
• 62-53-3 aniline 
• 622-74-2 N-phenyl-N'-p-tolyl-triazene 
• 2101-86-2 p-methylazidobenzene 
• 352-32-9 p-fluorotoluene 
• 583-68-6 2-bromo-p-toluidine 
• 100-61-8 N-methylaniline 

Downstream Products

• 1444922-93-3 C₃₁H₂₆AuN₃P⁽¹⁺⁾*CF₃O₃S^(1-) 
• 4630-20-0 3-Methyl-9H-carbazole 

Relevant articles and documents

Synthesis of functionized N-arylbenzotriazoles via palladium catalyzed intramolecular amination

The functionalized benzotriazoles are prepared by palladium catalyzed intramolecular amination of 2-bromodiaryltriazene. By screening the reaction conditions, such as ligand, solvent, base and reaction concentration, the optimal reaction conditions were o

Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.

Cu-catalyzed arylation of 1-acyl-1H-1,2,3-Benzotriazoles via C–N activation

An efficient copper-catalyzed arylation reaction of 1-acyl-1H-1,2,3-benzotriazoles with diaryliodonium salts via C–N activation is explored. The reaction is conducted regioselectively to form 1-aryl-1H-1,2,3-benzotriazoles in MeCN at 80 °C in the presence of cesium carbonate. 29 examples are given with the product yield of up to 84%. The probable reaction mechanism is proposed.