78790-82-6

Basic information

• Product Name: 1-(3-CHLORO-PYRIDIN-4-YL)-ETHANONE
• Synonyms: 1-(3-CHLORO-PYRIDIN-4-YL)-ETHANONE;1-(3-Chloro-4-pyridinyl)ethanone;1-(3-chloropyridin-4-yl)ethan-1-one
• CAS NO: 78790-82-6
• Molecular Formula: C7H6ClNO
• Molecular Weight: 155.5816
• Mol File: 78790-82-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 211℃
• Flash Point: 81℃
• Appearance: /
• Density: 1.233
• Vapor Pressure: 0.192mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.24±0.18(Predicted)
• CAS DataBase Reference: 1-(3-CHLORO-PYRIDIN-4-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-PYRIDIN-4-YL)-ETHANONE(78790-82-6)
• EPA Substance Registry System: 1-(3-CHLORO-PYRIDIN-4-YL)-ETHANONE(78790-82-6)

Safety Data

• Hazardous Substances Data: 78790-82-6(Hazardous Substances Data)

Usage

General Description

1-(3-chloro-pyridin-4-yl)-ethanone is a chemical compound that is used in various organic synthesis processes. It is a ketone that contains a chlorinated pyridine ring, making it a valuable building block for the production of pharmaceuticals, agrochemicals, and other fine chemicals. 1-(3-CHLORO-PYRIDIN-4-YL)-ETHANONE is known for its versatile reactivity and ability to undergo various chemical transformations, making it a valuable intermediate in the synthesis of a wide range of organic compounds. Its specific structure and properties make it a key component in the development of new and improved chemical products.

InChI:InChI=1/C7H6ClNO/c1-5(10)6-2-3-9-4-7(6)8/h2-4H,1H3

Upstream product

• 626-60-8 3-Chloropyridine 
• 110-19-0 2-methylpropyl acetate 
• 75-16-1 methylmagnesium bromide 
• 68325-15-5 3-chloro-isonicotinonitrile 
• 1187669-51-7 3-chloro-N-methyl-N-(methyloxy)-4-pyridinecarboxamide 
• 88912-27-0 3-chloro-isonicotinic acid 

Downstream Products

• 1187669-50-6 4-(3-chloro-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine 

Relevant articles and documents

4-Pyridylanilinothiazoles that selectively target von Hippel - Lindau deficient renal cell carcinoma cells by inducing autophagic cell death

Renal cell carcinomas (RCC) are refractory to standard therapy with advanced RCC having a poor prognosis; consequently treatment of advanced RCC represents an unmet clinical need. The von Hippel-Lindau (VHL) tumor suppressor gene is mutated or inactivated in a majority of RCCs. We recently identified a 4-pyridyl-2-anilinothiazole (PAT) with selective cytotoxicity against VHL-deficient renal cells mediated by induction of autophagy and increased acidification of autolysosomes. We report exploration of structure-activity relationships (SAR) around this PAT lead. Analogues with substituents on each of the three rings, and various linkers between rings, were synthesized and tested in vitro using paired RCC4 cell lines. A contour map describing the relative spatial contributions of different chemical features to potency illustrates a region, adjacent to the pyridyl ring, with potential for further development. Examples probing this domain validated this approach and may provide the opportunity to develop this novel chemotype as a targeted approach to the treatment of RCC. 2009 American Chemical Society.

Chemoselective Reactions of 3-Chloroisonicotinonitrile

Chemoselective reactions of 3-chloroisonicotinonitrile (1) with nucleophiles are described.Treatment of 1 with sodium methoxide/methanol results in formation of the imino ether, which can be further elaborated into a triazole ring.However, when 1 is react