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Carbocyclic Analogs of Thymine Nucleosides and Related 1-Substituted Thymines
Shealy, Y.Fulmer,O'Dell, C.Allen,Thorpe, Martha C.
, p. 383 - 389 (2007/10/02)
The carbocyclic analogs of thymidine (IXf), 1-β-ribofuranosylthymine (IXg), and 1-β-3'-deoxyribofuranosylthymine (IXe) were synthesized by incorporating modifications into the Shaw method of synthesizing 2,4-(1H,3H)pyrimidinediones via acryloylureas.Simpler analogs of thymine nucleosides were also prepared by this method.The carbocyclic analog of thymidine displayed modest activity against Leukemia L1210 in vivo.It differs from a compound prepared previously by a Prins reaction.
