788156-72-9Relevant academic research and scientific papers
Structural-activity relationship study on C-4 carbon atom of the CB 1 antagonist SR141716: Synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides
Jagerovic, Nadine,Hernandez-Folgado, Laura,Alkorta, Ibon,Goya, Pilar,Martin, Maria Isabel,Dannert, Maria Teresa,Alsasua, Angela,Frigola, Jordi,Cuberes, Maria Rosa,Dordal, Alberto,Holenz, Joerg
, p. 114 - 120 (2007/10/03)
A series of 1,2,4-triazole-3-carboxamides has been prepared from alkyl-1,2,4-triazole-3-carboxylates under mild conditions. The ability of these triazoles to displace [3H]-CP55940 from CB1 cannabinoid receptor was measured. However,
NEW 1,2,4-TRIAZOLE-3-CARBOXAMIDE DERIVATIVES
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Page/Page column 13-14, (2010/10/20)
The invention relates to new 1,2,4-triazole-3-carboxamide derivatives, as well as to their use for the treatment of diseases in which cannabinoid receptors are involved.
Bioisosteric replacements of the pyrazole moiety of rimonabant: Synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists
Lange, Jos H. M.,Van Stuivenberg, Herman H.,Coolen, Hein K. A. C.,Adolfs, Tiny J. P.,McCreary, Andrew C.,Keizer, Hiskias G.,Wals, Henri C.,Veerman, Willem,Borst, Alice J. M.,De Looff, Wouter,Verveer, Peter C.,Kruse, Chris G.
, p. 1823 - 1838 (2007/10/03)
Series of thiazoles, triazoles, and imidazoles were designed as bioisosteres, based on the 1,5-diarylpyrazole motif that is present in the potent CB1 receptor antagonist rimonabant (SR141716A, 1). A number of target compounds was synthesized an
1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE DERIVATIVES AS CANNABINOID-CB1 RECEPTOR LIGANDS
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Page/Page column 7, (2010/02/06)
The present invention relates to a group of 1H-1,2,4-triazole-3-carboxamide derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing at least one of these compounds as an active ingredient. These 1H-1,2
