78833-05-3Relevant articles and documents
Synthesis and antiarrhythmic activity of new [(dialkylamino)alkyl]pyridylacetamides
Bernhart,Condamine,Demarne,Roncucci,Gagnol,Gautier,Serre
, p. 451 - 455 (2007/10/02)
The synthesis of new [(dialkylamino)alkyl]pyridylacetamides is reported. These compounds displayed a potent antiarrhythmic activity, as demonstrated on a model of myocardial infarction in the conscious dog. Structure-activity relationships are discussed within a series of 22 homologues, comparing relative antiarrhythmic properties and cardiac side effects. One of these compounds, 15, has been selected as a candidate for clinical evaluation in man.
Myocardium-protecting pyridine derivatives having an anti-arrhythmic activity and an activity as blood-platelets antiaggregants
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, (2008/06/13)
The present invention relates to new pyridine derivatives of formula: STR1 wherein R1 is an alkyl or an alicyclic group, R2 and R3 are alkyls or alicyclic groups or form an heterocycle with the atom of nitrogen to which they are bonded; the invention also relates to a process for the preparation of said derivatives and the medicines containing at least one of the said derivatives.