78843-66-0Relevant articles and documents
The catalysis and asymmetric induction of chiral reverse micelle: Synthesis of optically active α-amino acids
Sun, Peipei,Zhang, Yongmin
, p. 4173 - 4179 (1997)
Through alkylation of N-benzylideneglycine ethyl ester in chiral reverse micelle, followed by hydrolysis of the resulting products, optically active α-amino acids were synthesized.
Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation
Korch, Katerina M.,Eidamshaus, Christian,Behenna, Douglas C.,Stoltz, Brian M.,Nam, Sangkil,Horne, David
supporting information, p. 179 - 183 (2015/02/05)
The asymmetric palladium-catalyzed decarboxylative allylic alkylation of differentially N-protected piperazin-2- ones allows the synthesis of a variety of highly enantioenriched tertiary piperazine-2-ones. Deprotection and reduction affords the corresponding tertiary piperazines, which can be employed for the synthesis of medicinally important analogues. The introduction of these chiral tertiary piperazines resulted in imatinib analogues which exhibited comparable antiproliferative activity to that of their corresponding imatinib counterparts.
N-substituted 3-acetyltetramic acid derivatives as antibacterial agents
Yendapally, Raghunandan,Hurdle, Julian G.,Carson, Elizabeth I.,Lee, Robin B.,Lee, Richard E.
, p. 1487 - 1491 (2008/12/21)
In order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. Key structural changes
