78867-89-7

Upstream product

• 2901-80-6 N-benzoyl-D,L-valine 
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• 78867-91-1 (2S)-2-(benzoylamino)-3-methylbutyric acid hydrazide 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 2901-80-6 N-benzoyl-L-valine 
• 186581-53-3 diazomethane 
• 98-88-4 benzoyl chloride 
• 20488-27-1 (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

MALT1 INHIBITORS AND USES THEREOF

Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

Dynamic kinetic resolution of N-benzoyl-DL-amino acids via peptide bond forming reactions

Dynamic kinetic resolution (DKR) was demonstrated in the carbodiimide-mediated couplings of N-benzoyl-DL-amino acids with L-amino acid esters: the yields of the D-L-peptides significantly exceeded 50% in some cases. N-benzoyl-DL-t-leucine afforded the D-L-peptide almost exclusively (up to 96% yield) in the reaction with methyl L-prolinate, which is the most efficient DKR obtained in the field of amino acids and derivatives.

Studies on the Diastereoisomeric and Conformational Aspects of Benzoyl Dipeptide Esters, as a Means of assessing Racemisation using Nuclear Magnetic Resonance Spectroscopy

Distinct methyl ester signals in the 1H n.m.r. spectra of diastereoisomeric forms of benzoyl dipeptide methyl esters provide a means of estimating the isomer composition of diastereoisomeric mixtures.Analysis of the mixture derived from peptide-coupling r