78867-91-1

Upstream product

• 2901-80-6 N-benzoyl-L-valine 
• 1492-13-3 N-benzoyl-L-valine methyl ester 
• 72-18-4 L-valine 
• 98-88-4 benzoyl chloride 
• 640-68-6 D-Val-OH 
• 1492-13-3 (2R)-2-(benzoylamino)-3-methylbutyric acid methyl ester 
• 28897-81-6 (S)-4-isopropyl-2-phenyl-4H-oxazol-5-one 
• 2901-80-6 (2R)-2-(benzoylamino)-3-methylbutyric acid 

Downstream Products

• 1452784-82-5 (2R)-2-(benzoylamino)-3-methyl-N'-(2-fluorobenzylidene)butanohydrazide 
• 1452784-83-6 (2R)-2-(benzoylamino)-3-methyl-N'-(2,6-difluorobenzylidene)butanohydrazide 
• 1452784-84-7 (2R)-2-(benzoylamino)-3-methyl-N'-(2-chloro-6-fluorobenzylidene)butanohydrazide 
• 78867-89-7 benzoyl-L-valyl-L-proline methyl ester 
• 1452784-60-9 (2S)-2-(benzoylamino)-3-methyl-N'-(4-chlorobenzylidene)butanohydrazide 
• 1452784-61-0 (2S)-2-(benzoylamino)-3-methyl-N'-(2-chlorobenzylidene)butanohydrazide 
• 1452784-62-1 (2S)-2-(benzoylamino)-3-methyl-N'-(2,6-dichlorobenzylidene)butanohydrazide 
• 1452784-63-2 (2S)-2-(benzoylamino)-3-methyl-N'-(2,4-dichlorobenzylidene)butanohydrazide 
• 1452784-64-3 (2S)-2-(benzoylamino)-3-methyl-N'-(2-fluorobenzylidene)butanohydrazide 
• 1452784-65-4 (2S)-2-(benzoylamino)-3-methyl-N'-(3-fluorobenzylidene)butanohydrazide 
• 1452784-66-5 2-(benzoylamino)-3-methyl-N'-(4-fluorobenzylidene)butanohydrazide 
• 1452784-67-6 (2S)-2-(benzoylamino)-3-methyl-N'-(2,6-difluorobenzylidene)butanohydrazide 
• 1452784-68-7 (2S)-2-(benzoylamino)-3-methyl-N'-(2-chloro-6-fluorobenzylidene)butanohydrazide 
• 1452784-69-8 2-(benzoylamino)-3-methyl-N'-(4-trifluoromethylbenzylidene)butanohydrazide 

Relevant academic research and scientific papers

Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: Synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1

In accordance with our antiviral drug development attempt, acylhydrazone derivatives bearing amino acid side chains were synthesized for the evaluation of their antiviral activity against various types of viruses. Among these compounds, 8S, 11S, and 12S showed anti-HIV-1 activity with a 50% inhibitory concentration (IC50) = 123.8 μM (selectivity index, SI > 3), IC50 = 12.1 μM (SI > 29), IC50 = 17.4 μM (SI > 19), respectively. Enantiomers 8 R, 11R, and 12R were inactive against the HIV-1 strain IIIB. Hydrazones 8S, 11S, and 12 S which were active against HIV-1 wild type showed no inhibition against a double mutant NNRTI-resistant strain (K103N;Y181C). Molecular docking calculations of R- and S-enantiomers of 8, 11, and 12 were performed using the hydrazone-bound novel site of HIV-1 RT. Copyright

STUDIES ON THE KINETICS OF RACEMIZATION OF 2,4-DISUBSTITUTED-5(4H)-OXAZOLONES

The kinetics of racemization of 2,4-disubstituted-5(4H)-oxazolones obtained from N-acetyl, N-benzoyl, and N-benzyloxycarbonylglycyl-L-leucine, -valine, and -phenylalanine have been studied in several solvents alone and in the presence of tertiary amines.T