78868-49-2

Basic information

• Product Name: methyl {4-[5-(4-fluorophenyl)isoxazol-3-yl]phenyl}acetate
• CAS NO: 78868-49-2
• Molecular Formula: C₁₈H₁₄FNO₃
• Molecular Weight: 311.3071
• Mol File: 78868-49-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 459.6°C at 760 mmHg
• Flash Point: 231.7°C
• Density: 1.23g/cm³
• Vapor Pressure: 1.25E-08mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: methyl {4-[5-(4-fluorophenyl)isoxazol-3-yl]phenyl}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl {4-[5-(4-fluorophenyl)isoxazol-3-yl]phenyl}acetate(78868-49-2)
• EPA Substance Registry System: methyl {4-[5-(4-fluorophenyl)isoxazol-3-yl]phenyl}acetate(78868-49-2)

Safety Data

• Hazardous Substances Data: 78868-49-2(Hazardous Substances Data)

Upstream product

• 78868-33-4 {4-[2,3-Dibromo-3-(4-fluoro-phenyl)-propionyl]-phenyl}-acetic acid 
• 78868-26-5 {4-[(E)-3-(4-Fluoro-phenyl)-acryloyl]-phenyl}-acetic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 7398-52-9 4-acetyl-phenylacetic acid 
• 67-56-1 methanol 
• 78868-41-4 {4-[5-(4-Fluoro-phenyl)-isoxazol-3-yl]-phenyl}-acetic acid 

Relevant articles and documents

Anti-inflammatory Agents: Part IV - Synthesis and Anti-inflammatory Activity of 4-(5-Arylisoxazol-3-yl)phenylalkanoic Acids and Their Methyl Esters

The methyl esters (8a-d and 9a-d) of 4-(5-arylisoxazol-3-yl)phenylacetic and -phenyl-α-methylacetic acids (6a-d and 7a-d) have been synthesized from the corresponding chalkone dibromides (4a-d and 5a-d) by treatment with NH2OH.HCl in NaOH, followed by esterification of acids thus obtained.The anti-inflammatory activity of 6-9 has been evaluated.The most active compound 4-(5-phenylisoxazol-3-yl)phenyl-α-methylacetic acid (7a) showing 48.68percent inhibition is equipotent with phenylbutazone, but inactive in adjuvent induced arthritis test.