7398-52-9

Basic information

• Product Name: (4-acetylphenyl)acetic acid
• Synonyms: (4-acetylphenyl)acetic acid;2-(4-Acetylphenyl)acetic acid
• CAS NO: 7398-52-9
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• Mol File: 7398-52-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 117℃
• Boiling Point: 356.51°C at 760 mmHg
• Flash Point: 183.601°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4-acetylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-acetylphenyl)acetic acid(7398-52-9)
• EPA Substance Registry System: (4-acetylphenyl)acetic acid(7398-52-9)

Safety Data

• Hazardous Substances Data: 7398-52-9(Hazardous Substances Data)

Usage

General Description

(4-Acetylphenyl)acetic acid is an organic compound that belongs to the class of organic compounds known as acetophenones. These compounds comprise an acetophenone moiety which consists of a phenyl group substituted at the second position by an acetate group. As per its chemical structure, it is formed by having an acetophenone moiety substituted with an acetic acid at the phenyl ring. It is often used in organic synthesis and can be utilized as an intermediate in the production of various types of pharmaceuticals, dyes and other chemicals. Given its chemical properties, safety measures should be taken into consideration while handling them so as to prevent exposure which might be harmful.

InChI:InChI=1/C10H10O3/c1-7(11)9-4-2-8(3-5-9)6-10(12)13/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 10266-42-9 2-(4-acetylphenyl)acetonitrile 
• 124-38-9 carbon dioxide 
• 54589-56-9 4-chloromethylacetophenone 
• 99-91-2 para-chloroacetophenone 
• 13329-40-3 4-Iodoacetophenone 
• 64-19-7 acetic acid 
• 408334-85-0 4-(1,1-diethoxy-ethyl)-benzoic acid ethyl ester 
• 408334-58-7 1-(4-hydroxymethyl-phenyl)-ethanone-diethylacetal 
• 75633-63-5 4-(hydroxymethyl)acetophenone 
• 38430-55-6 ethyl-4-acetylbenzoate 
• 122-00-9 para-methylacetophenone 
• 51229-51-7 4-acetylbenzyl bromide 
• 143-33-9 sodium cyanide 
• 1528-42-3 ethyl 4-acetylphenylacetate 

Downstream Products

• 501-89-3 4-(carboxymethyl)benzoic acid 
• 7325-46-4 1,4-phenylenediacetic acid 
• 855935-31-8 (4-(1-hydroxy)ethylphenyl)acetic acid 
• 113787-93-2 N-(p-acetylphenyl)acetyl-L-(S-p-methoxybenzylcysteinyl)-D-valine benzhydryl ester 
• 947546-98-7 (4-acetylphenyl)acetyl chloride 
• 78868-26-5 {4-[(E)-3-(4-Fluoro-phenyl)-acryloyl]-phenyl}-acetic acid 
• 78868-27-6 {4-[(E)-3-(4-Methoxy-phenyl)-acryloyl]-phenyl}-acetic acid 
• 113787-96-5 (p-acetylphenyl)acetyl-L-cysteinyl-D-valine 
• 113787-99-8 (2S,5R,6R)-6-[2-(4-Acetyl-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 78868-34-5 {4-[2,3-Dibromo-3-(4-methoxy-phenyl)-propionyl]-phenyl}-acetic acid 
• 78868-32-3 4'-Carboxymethyl-4-chlorochalkone dibromide 
• 78868-33-4 {4-[2,3-Dibromo-3-(4-fluoro-phenyl)-propionyl]-phenyl}-acetic acid 
• 78868-50-5 {4-[5-(4-Methoxy-phenyl)-isoxazol-3-yl]-phenyl}-acetic acid methyl ester 
• 78868-48-1 Methyl 4-(5-p-chlorophenylisoxazol-3-yl)phenylacetate 

Relevant articles and documents

Non-natural amino acid and application thereof Recombinant protein and recombinant protein conjugate comprising same

The invention provides a non-natural amino acid. A compound represented by formula (I) or an enantiomer thereof. The invention also provides application of the non-natural amino acid. Further, the present invention also provides a protein conjugate comprising the recombinant protein and of the non-natural amino acid prepared from the recombinant protein. The non-natural amino acid provided by the invention is simple and convenient to prepare, good in safety, not prone to inactivation during protein insertion, high in conjugate rate with a coupling part, and higher in stability of the obtained conjugate.

Palladium-Catalyzed Carboxylation of Benzyl Chlorides with Atmospheric Carbon Dioxide in Combination with Manganese/Magnesium Chloride

An efficient direct carboxylation of a series of benzyl chlorides with CO2 catalyzed by Pd(OAc)2/dicyclohexyl (2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine (SPhos) was developed to afford the corresponding phenylacetic acids in combination with Mn powder as a reducing reagent and MgCl2 as an indispensable additive. The reaction proceeded smoothly under 1 atm CO2. The application of Mn powder instead of a sensitive reducing reagent represents an operationally simple access to phenylacetic acids. Notably, MgCl2 is able to stabilize the (SPhos)2PdII(Bn)(Cl)(η1-CO2)(MgCl2) adduct and thus facilitates CO2 insertion into the PdII-C bond, which is supported by a DFT study. Specific effect: MgCl2 facilitates the direct insertion of CO2 into the PdII-C bond by stabilizing the PdII-CO2 adduct. With MgCl2 as an indispensable additive, the Pd-catalyzed carboxylation of various benzyl chlorides proceeded smoothly under 1 atm CO2, and the application of Mn powder instead of a sensitive reducing reagent makes this protocol an operationally simple access to phenylacetic acids.

Ni-catalyzed direct carboxylation of benzyl halides with CO2

A novel Ni-catalyzed carboxylation of benzyl halides with CO2 has been developed. The described carboxylation reaction proceeds under mild conditions (atmospheric CO2 pressure) at room temperature. Unlike other routes for similar means, our method does not require well-defined and sensitive organometallic reagents and thus is a user-friendly and operationally simple protocol for assembling phenylacetic acids.