78871-04-2

Basic information

• Product Name: (R)-1-oxopropan-2-yl benzoate
• Synonyms: (R)-1-oxopropan-2-yl benzoate
• CAS NO: 78871-04-2
• Molecular Weight: 178.188
• Mol File: 78871-04-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (R)-1-oxopropan-2-yl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-oxopropan-2-yl benzoate(78871-04-2)
• EPA Substance Registry System: (R)-1-oxopropan-2-yl benzoate(78871-04-2)

Safety Data

• Hazardous Substances Data: 78871-04-2(Hazardous Substances Data)

Upstream product

• 159716-56-0 C₂₀H₂₂O₆ 
• 65-85-0 benzoic acid 
• 113566-74-8 [(1R)-2-hydroxy-1-methyl-ethyl]benzoate 
• 871580-89-1 [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate 
• 201230-82-2 carbon monoxide 
• 769-78-8 vinyl benzoate 
• 159716-54-8 (2R,3R,4R,5R)-2,5-dibenzoyloxy-3,4-O-(1-methylethylidene)-3,4-hexanediol 

Downstream Products

• 159716-58-2 Benzoic acid (E)-(R)-1-methyl-4-oxo-but-2-enyl ester 
• 113566-74-8 [(1R)-2-hydroxy-1-methyl-ethyl]benzoate 
• 159716-63-9 Benzoic acid (E)-(R)-4,4-dimethoxy-1-methyl-but-2-enyl ester 

Relevant articles and documents

Asymmetric Hydroformylation of Heterocyclic Olefins Mediated by Supramolecularly Regulated Rhodium-Bisphosphite Complexes

Rhodium complexes derived from conformationally transformable α,ω-bisphosphite ligands combined with a suitable alkali metal BArF salt as a regulation agent (RA) provide high regio- and enantioselectivities in the asymmetric hydroformylation (AHF) of three heterocyclic olefins. The outcome of the AHF could be exquisitely regulated by choosing the appropriate RA with an increase in the ee, the reversal of the regioselectivity, or the complete suppression of one byproduct.

Asymmetric Hydroformylation Using a Rhodium Catalyst Encapsulated in a Chiral Capsule

Supramolecular capsules can be used to change the activity and selectivity of a catalyst through the influence of the second coordination sphere, reminiscent of how enzymes control the selectivity of their processes. In enzymes, this approach is used to also control the enantioselectivity of reactions in which the active catalytic site is often not chiral but the second coordination sphere is. We are interested in the possibility to generate a chiral second coordination sphere around an otherwise achiral transition metal complex for asymmetric catalysis. In this paper we show that the ligand template approach can be used to generate a chiral second coordination sphere around a rhodium complex, which is used in asymmetric hydroformylation.

Supramolecularly Regulated Ligands for Asymmetric Hydroformylations and Hydrogenations

Herein we report the use of polyether binders as regulation agents (RAs) to enhance the enantioselectivity of rhodium-catalyzed transformations. For reactions of diverse substrates mediated by rhodium complexes of the α,ω-bisphosphite-polyether ligands 1-5,a-d, the enantiomeric excess (ee) of hydroformylations was increased by up to 82 (substrate: vinyl benzoate, 96ee), and the ee value of hydrogenations was increased by up to 5 (substrate: N-(1-(naphthalene-1-yl)vinyl)acetamide, 78ee). The ligand design enabled the regulation of enantioselectivity by generation of an array of catalysts that simultaneously preserve the advantages of a privileged structure in asymmetric catalysis and offer geometrically close catalytic sites. The highest enantioselectivities in the hydroformylation of vinyl acetate with ligand 4b were achieved by using the Rb[B(3,5-(CF3)2C6H3)4] (RbBArF) as the RA. The enantioselective hydrogenation of the substrates 10 required the rhodium catalysts derived from bisphosphites 3a or 4a, either alone or in combination with different RAs (sodium, cesium, or (R,R)-bis(1-phenylethyl)ammonium salts). This design approach was supported by results from computational studies.