871580-89-1

Upstream product

• 136918-07-5 (2R)-1[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-propanol 
• 65-85-0 benzoic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 78871-04-2 (R)-1-oxopropan-2-yl benzoate 
• 871580-90-4 (1R)-2-bromo-1-methylethyl benzoate 
• 113566-74-8 [(1R)-2-hydroxy-1-methyl-ethyl]benzoate 

Relevant academic research and scientific papers

PRODRUGS OF CHLOROKYNURENINES

The present disclosure relates to prodrugs of 7-chlorokynurenic acid. In certain embodiments, the prodrugs include those having the structure of any one of formula (I)-(VIII), wherein R1-R13, monomer 1, monomer 2, and linker are defi

Enantioselective syn and anti homocrotylation of aldehydes: Application to the formal synthesis of spongidepsin

Whereas crotylboration has been a useful method for synthesis of stereochemically complex products, we have shown that homocrotylboration can be achieved with cyclopropanated crotylation reagents, and that the stereoselectivity of the reaction can be predicted by analogous models. This paper presents a full account of this work, including the first examples of asymmetric anti homocrotylation. The scope of this reaction is demonstrated with highly enantioselective homocrotylation of both aliphatic and aromatic aldehydes, as well as double diastereoselection studies. An application of the synthesis of the marine natural product spongidepsin is presented, as well as streamlined syntheses of homocrotylation reagents.

LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF

Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR6-; n is an

Lipase-catalyzed alcoholysis of diol dibenzoates: Selective enzymatic access to the 2-benzoyl ester of 1,2-propanediol and preparation of the enantiomerically pure (R)-1-O-benzoyl-2-methylpropane-1,3-diol

Enzymatic debenzoylation of 1,2-propanediol dibenzoate with 1-octanol has been studied in organic solvent using lipases from different sources. In general a slow, highly regioselective alcoholysis in diisopropyl ether affords exclusively a monoester benzoylated at the secondary hydroxy group although the reaction proceeds with low enantioselectivity. In the presence of Pseudomonas cepacia lipase absorbed onto celite, a faster reaction allows the preparation of the 2-benzoyl ester of (R)-1,2-propanediol (82% ee) and the enantiomerically pure (R)-1-O-benzoyl-2-methylpropane-1,3-diol (>98% ee).