78902-62-2

Upstream product

• 31898-69-8 4-(phenylthio)azetidin-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 108-98-5 thiophenol 
• 97721-47-6 3-(phenylsulfanyl)propanamide 
• 51849-21-9 β-(phenylthio)propionyl chloride 
• 5219-65-8 acide phenylthio-3 propanoique 
• 22198-59-0 methyl 3-phenylthiopropanoate 
• 49639-35-2 3-(phenylsulfinyl)propionamide 
• 77086-38-5 ketene t-butyldimethylsilyl methyl acetal 

Downstream Products

• 117539-82-9 3-trimethylsilyl-4-thiophenyl-1-tert-butyldimethylsilylazetidin-2-one 
• 82342-05-0 2-[1-(tert-Butyl-dimethyl-silanyl)-4-oxo-azetidin-2-yl]-2-phenylsulfanyl-malonic acid dimethyl ester 
• 129329-65-3 N-(tert-butyldimethylsilyl)-4-(phenylsulfinyl)azetidin-2-one 
• 79759-95-8 (3S*,4R*)-N-(tert-butyldimethylsilyl)-3-ethyl-4-(phenylthio)azetidin-2-one 
• 78902-63-3 (3R,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-(1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one 
• 78902-63-3 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one 
• 79759-97-0 3,4-trans-3-ethyl-4-phenylsulphonyl-2-azetidinone 
• 79759-96-9 3,4-trans-1-(tert-butyldimethylsilyl)-3-ethyl-4-phenylsulfonyl-2-azetidinone 
• 80813-16-7 (+/-)-3α-<(R)-1-(tert-butyldimethylsilyloxy)ethyl>-4β-phenylsulfonyl-2-azetidinone 
• 80813-15-6 (+/-)-1-(tert-butyldimethylsilyl)-3α-<(R)-1-(tert-butyldimethylsilyloxy)ethyl>-4β-phenylsulfonyl-2-azetidinone 
• 78902-64-4 (3R,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-phenylsulfanyl-azetidin-2-one 
• 78902-64-4 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-phenylsulfanyl-azetidin-2-one 
• 78902-64-4 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-phenylsulfanyl-azetidin-2-one 

Relevant academic research and scientific papers

Inhibition of serine proteases: Activity of 1,3-diazetidine-2,4-diones

The present work demonstrates that the 1,3-diazetidine-2,4-dione nucleus is effective as a scaffold of serine protease inhibitors. Compound 1 displayed high activity against human cathepsin G and α-chymotrypsin (0.39, 0.69 nM). Compound 6 exhibited 0.85 nM inhibition of human chymase. Compound 10 was a selective inhibitor against human neutrophil elastase.

Chemistry of O-silylated ketene acetals: A mild and convenient synthesis of β-lactam antibiotics

β-Amido sulfoxides (1) reacted with O-silylated ketene acetal (16) in dry acetonitrile in the presence of a catalytic amount of zinc iodide to give the 4-phenylthioazetidin-2-ones (17). Oxidation of 17 with m-chloroperbenzoic acid gave the corresponding s