22198-59-0Relevant academic research and scientific papers
DESILYLATION OF α-TRIMETHYLSILYLMETHYLENE-γ-LACTONES. A NEW ROUTE TO α-METHYLENE-γ-LACTONES
Bachi, Mario D.,Bosch, Eric
, p. 2581 - 2584 (1988)
Addition of phenylthiol to α-trimethylsilylmethylene-γ-lactones affords α-phenylthio(trimethylsilyl)methyl-γ-lactones which, on treatment with tetrabutylammonium fluoride and methyl acrylate give the corresponding α-methylene-γ-lactones through a one-pot double deblocking process.
CuI-catalyzed tandem synthesis of thioethers using aryl halides, electron-deficient alkenes, and sodium iso-propyl xanthogenate
Abbasi, Mohammad,Nowrouzi, Najmeh,Khezri, Rahimeh
, (2020)
A ligand-free, CuI-catalyzed protocol was developed for the one-step preparation of Michael adducts of aromatic thiols in high yields by reacting a mixture of an aryl halide and an electron-deficient alkene with sodium iso-propyl xanthogenate.
Investigation of synthetic routes towards derivatives of 3-(phenylsulfonimidoyl)propanoic acid
Tye, Heather,Skinner, Catharine L.
, p. 3272 - 3282 (2002)
The synthesis of a range of 3-(phenylsulfonimidoyl)propanoate derivatives is described. A number of strategies for the imination of the key sulfoxide methyl 3-(penylsulfinyl)propanoate are discussed including the use of O-(mesitylsulfonyl)hydroxylamine (M
A novel synthesis of β-arylthio propanoic esters promoted by low- valent titanium
Shi, Daqing,Lu, Zaisheng,Mu, Lailong,Dai, Guiyuan
, p. 1073 - 1078 (1998)
Promoted by low-valent titanium, aryl sulfonyl chlorides react with α,β-unsaturated esters in THF to give β-arylthio propanoic esters in moderate to good yields.
Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific Sulfur–Fluorine Exchange (SuFEx) Reaction
Greed, Stephanie,Briggs, Edward L.,Idiris, Fahima I. M.,White, Andrew J. P.,Lücking, Ulrich,Bull, James A.
supporting information, p. 12533 - 12538 (2020/09/16)
Sulfonimidamides present exciting opportunities as chiral isosteres of sulfonamides, with potential for additional directional interactions. Here, we present the first modular enantioselective synthesis of sulfonimidamides, including the first stereoselective synthesis of enantioenriched sulfonimidoyl fluorides, and studies on their reactivity. A new route to sulfonimidoyl fluorides is presented from solid bench-stable, N-Boc-sulfinamide (Boc=tert-butyloxycarbonyl) salt building blocks. Enantioenriched arylsulfonimidoyl fluorides are shown to be readily racemised by fluoride ions. Conditions are developed, which trap fluoride and enable the stereospecific reaction of sulfonimidoyl fluorides with primary and secondary amines (100 % es, es=enantiospecificity) generating sulfonimidamides with up to 99 % ee. Aryl and alkyl sulfonimidoyl fluoride reagents are suitable for mild late stage functionalisation reactions, exemplified by coupling with a selection of complex amines in marketed drugs.
Zinc complexes supported by pyridine-: N -oxide ligands: Synthesis, structures and catalytic Michael addition reactions
Chen, Ze-Wen,He, Piao,Liu, Chao,Mo, Xiu-Fang,Tong, Hai-Xia,Xiong, Chang-Feng,Yi, Xiao-Yi
, p. 12365 - 12371 (2020/10/02)
New dipyridylpyrrole N-oxide ligands HL1 and HL2 are designed and synthesized via oxidation of 2-(5-(pyridin-2-yl)-1H-pyrrol-2-yl)pyridine (Hdpp) by using 3-chloroperbenzoic acid (m-CPBA) in CH2Cl2. The treatment of ZnEt2 with two equiv. of HL1 and HL2 af
Synthesis of curcumin derivatives and analysis of their antitumor effects in triple negative breast cancer (TNBC) cell lines
Bonaccorsi, Paola Maria,Labbozzetta, Manuela,Barattucci, Anna,Salerno, Tania Maria Grazia,Poma, Paola,Notarbartolo, Monica
, (2020/01/29)
We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original proce
Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds
Wu, Shengfeng,Lei, Xiaofang,Fan, Erkang,Sun, Zhihua
supporting information, p. 522 - 525 (2018/02/10)
Direct reaction of isocyanides with some sulfenic-acid-generating sulfoxides led to the effective formation of the corresponding thiocarbamic acid S-esters in good to high yields. A multicomponent reaction involving isocyanide, sulfoxide, and a suitable nucleophile has also been developed, providing ready access to a diverse range of sulfur-containing compounds, including isothioureas, carbonimidothioic acid esters, and carboximidothioic acid esters.
On-water magnetic NiFe2O4 nanoparticle-catalyzed Michael additions of active methylene compounds, aromatic/aliphatic amines, alcohols and thiols to conjugated alkenes
Payra, Soumen,Saha, Arijit,Banerjee, Subhash
, p. 95951 - 95956 (2016/10/25)
Here, we have demonstrated the Michael addition of active methylene compounds, aromatic/aliphatic amines, thiols and alcohols to conjugated alkenes using magnetic nano-NiFe2O4 as reusable catalyst in water. Nano-NiFe2O4 efficiently catalyzed the formation of C-C and C-X (X = N, S, O etc.) bond through 1,4-addition reactions.
NOVEL DENTAL COMPOSITES SYSTEMS AND METHODS OF MAKING THE SAME AND USING SAME
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Paragraph 0167; 0172; 0173; 0174, (2015/09/28)
The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer, and optionally an isocyanate monomer. The invention further includes a composition comprising a composition comprising the tetra(2-mercapto)silane (SiTSH) monomer an
