78905-64-3Relevant academic research and scientific papers
Direct C-H Arylation and Alkylation of Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents
Peng, Zhihua,Yu, Chuanman,Wang, Yilei,Wei, Dongyue,Jiang, Cuiyu
, p. 3678 - 3688 (2021/11/16)
A direct and convenient method for the C-H arylation and alkylation of electron-deficient N-heteroarenes with readily available organozinc reagents has been developed. This transformation could be readily performed in the absence of a transition-metal catalyst and external oxidants, affording a wide range of substituted heteroarenes with good functional group tolerance in good to excellent yields. The developed simple protocol is scalable to the gram level and suitable for late-stage modification of bioactive molecules and drugs.
Photoinitiated Substitution Reactions of Heterocyclic Bases: Reaction with Alkenes
Bernardi, Rosanna,Caronna, Tullio,Morrocchi, Sergio,Traldi, Piero,Vittimberga, Bruno M.
, p. 1607 - 1609 (2007/10/02)
A method is described for the synthesis of allyl heterocyclic bases by a photoinduced substitution reaction of cyanoheterocyclic bases and certain alkenes.
