2973-27-5 Usage
General Description
4-Cyanoquinoline is a chemical compound with the molecular formula C10H10N2 that belongs to the quinoline class of compounds. It is a pale yellow solid with a characteristic odor and is used primarily as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The presence of the cyano group in the molecule makes it a versatile precursor for the preparation of various functionalized quinoline derivatives. 4-Cyanoquinoline is also known for its potential biological activities such as anticancer, antimalarial, and antiviral properties, making it an important target for research and drug development. However, it is important to handle this chemical with caution due to its potential hazardous effects on health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 2973-27-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,7 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2973-27:
(6*2)+(5*9)+(4*7)+(3*3)+(2*2)+(1*7)=105
105 % 10 = 5
So 2973-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H6N2/c11-7-8-5-6-12-10-4-2-1-3-9(8)10/h1-6H
2973-27-5Relevant articles and documents
C?H Cyanation of 6-Ring N-Containing Heteroaromatics
Elbert, Bryony L.,Farley, Alistair J. M.,Gorman, Timothy W.,Johnson, Tarn C.,Genicot, Christophe,Lallemand, Bénédicte,Pasau, Patrick,Flasz, Jakub,Castro, José L.,MacCoss, Malcolm,Paton, Robert S.,Schofield, Christopher J.,Smith, Martin D.,Willis, Michael C.,Dixon, Darren J.
supporting information, p. 14733 - 14737 (2017/10/07)
Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.
