78906-11-3Relevant articles and documents
A 2 - hydroxy isopropyl substituted preparation method of acetophenone (by machine translation)
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Paragraph 0071; 0072; 0073; 0074; 0075; 0076, (2019/01/23)
The invention relates to a method for synthesizing 2 - hydroxy isopropyl substituted acetophenone method, it includes S1: in the 130 - 140 °C temperature, will be acetyl benzoic acid methyl ester and ethylene glycol in the organic solvent and the presence of a catalyst under the conditions of the reaction, generating comprises intermediate reaction mixture 1st; S2: the 1st reaction mixture is cooled to room temperature, the reaction mixture purification 1st, get midbody; S3: in - 5 to 0 °C temperature, in an inert atmosphere environment, the intermediate of the tetrahydrofuran solution dripped into methyl bromide in tetrahydrofuran solution of the magnesium oxide, the method comprises generating the 2 - hydroxy isopropyl substituted acetophenone 2nd reaction mixture; and S4: purifying the 2nd reaction mixture, to obtain the 2 - hydroxy isopropyl substituted acetophenone; wherein said alkali comprises acyl benzoic acid methyl ester 4 - acetyl benzoic acid methyl ester or 3 - acetyl-benzoic acid methyl ester. The methods of the invention and is simple, preparation procedure is simple and convenient, high yield, small pollution to the environment. (by machine translation)
Palladium on Carbon-Catalyzed Chemoselective Oxygen Oxidation of Aromatic Acetals
Yasukawa, Naoki,Asai, Shota,Kato, Maho,Monguchi, Yasunari,Sajiki, Hironao,Sawama, Yoshinari
supporting information, p. 5604 - 5607 (2016/11/17)
The development of an unprecedented chemoselective transformation has contributed to forming a novel synthetic process for target molecules. Chemoselective oxidation of aromatic acetals has been accomplished using a reusable palladium on carbon catalyst under atmospheric oxygen conditions to form ester derivatives with tolerance of aliphatic acetals and ketals.
Direct synthesis of protected arylacetaldehydes by tetrakis(phosphane)- palladium-catalyzed arylation of ethyleneglycol vinyl ether
Kondolff, Isabelle,Doucet, Henri,Santelli, Maurice
, p. 765 - 774 (2007/10/03)
A range of aryl bromides undergo Heck reaction with ethylene glycol vinyl ether, in the presence of [PdCl(C3H5)]2/ cis,cis,cis-1,2,3,4-tetrakis[(diphenylphosphanyl)methyl]cyclopentane as catalyst, to give regioselectively protected arylacetaldehydes in good yields. The β-arylation products were obtained in with 93-100 % selectivity with electron-poor aryl bromides or heteroaryl bromides. Furthermore, this catalyst can be used at low loading, even for reactions with sterically hindered aryl bromides. The aryl vinyl ether intermediates undergo subsequent ketalisation to give the corresponding 2-benzyl-1,3-dioxolane derivatives. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.