78906-12-4Relevant articles and documents
Palladium on Carbon-Catalyzed Chemoselective Oxygen Oxidation of Aromatic Acetals
Yasukawa, Naoki,Asai, Shota,Kato, Maho,Monguchi, Yasunari,Sajiki, Hironao,Sawama, Yoshinari
supporting information, p. 5604 - 5607 (2016/11/17)
The development of an unprecedented chemoselective transformation has contributed to forming a novel synthetic process for target molecules. Chemoselective oxidation of aromatic acetals has been accomplished using a reusable palladium on carbon catalyst under atmospheric oxygen conditions to form ester derivatives with tolerance of aliphatic acetals and ketals.
Experimental investigations of a partial Ru-O bond during the metal-ligand bifunctional addition in noyori-type enantioselective ketone hydrogenation
Takebayashi, Satoshi,Dabral, Nupur,Miskolzie, Mark,Bergens, Steven H.
supporting information; experimental part, p. 9666 - 9669 (2011/08/07)
The transition state for the metal-ligand bifunctional addition step in Noyori's enantioselective ketone hydrogenation was investigated using intramolecular trapping experiments. The bifunctional addition between the Ru dihydride trans-[Ru((R)-BINAP)(H)2((R,R)-dpen)] and the hydroxy ketone 4-HOCH2C6H4(CO)CH3 at -80 °C exclusively formed the corresponding secondary ruthenium alkoxide trans-[Ru((R)-BINAP)(H)(4-HOCH2C6H4CH(CH 3)O)((R,R)-dpen)]. Combined with the results of control experiments, this observation provides strong evidence for the formation of a partial Ru-O bond in the transition state.
Ester derivatives and pharmaceutical compositions containing them
-
, (2008/06/13)
The invention concerns ester derivatives of the formula I wherein Ar is phenyl, naphthyl, indenyl, indanyl, a 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from
OXIME DERIVATIVES
-
, (2008/06/13)
The invention concerns oxime derivatives of the formula I wherein R4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di(1-4C)alkylamino and (1-4C)alkyl; RS includes hydrogen, (1-4C)alkyl, (3-4C)alkeny1,(3-4C)alkynyl, (2-5C)alkanoyl, halogeno-(2-4-C)alkyl and hydroxy-(2-4C)alky1;Arl is phenylene or a hetercaryl diradical; Al is a direct link to XI, or Al is (1-4C)alkylene; XI is oxy, thio, sulphinyl or sulphonyl; Ar2 is phenylene or a heteroaryl diradical; RI is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkyny1; and R2 and R3 together form a group of the formula -A2. X2-A3- which together with the carbon atom to which A2 and A3 are attached define a ring having 5 or 6 ring atoms, wherein each of A2 and A3 is (1-3C)alkylene and X2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable sah thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
Free Radical Reactions in Solution. Part 6. Thermal Decomposition of Substituted Dibenzyl Mercurials in Solution. An improved ?. Scale
Dinctuerk, Suphi,Jackson, Richard A.,Townson, Michael,Agirbas, Hikmet,Billingham, Norman C.,March, Gary
, p. 1121 - 1126 (2007/10/02)
The kinetics of the decomposition of ten substituted dibenzylmercury compounds in solution have been determined in the temperature range 126-156 deg C.From the relative rates at 140.2 deg C, a new scale of substituent constants ?. applicable to
