78932-94-2

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 14960-95-3 1-(4-nitro-phenyl)-4-phenyl-piperazine 
• 92-54-6 4-phenyl-1-piperazine 
• 135-02-4 ortho-anisaldehyde 
• 68944-97-8 4-(4-phenyl-piperazine-1-yl)-phenylamine 

Downstream Products

• 78933-03-6 (2-Methoxy-benzyl)-[4-(4-phenyl-piperazin-1-yl)-phenyl]-amine 

Relevant academic research and scientific papers

Compounds Acting on CVS : Part I - Synthesis of 1-(p-Substituted-benzylaminophenyl)-4-arylpiperazines

1-(p-Nitrophenyl)-4-arylpiperazines (II), prepared by the reaction of various arylpiperazines with p-chloronitrobenzene, on reduction with Raney nickel give the corresponding 1-(p-aminophenyl)-4-arylpiperazines (III) which are converted into 1-(p-arylideneaminophenyl)-4-arylpiperazines (IV) by condensation with appropriate araldehydes.Reduction of IV with Pd/C im DMF furnishes the title compounds.Some of these compounds have been found to possess marked cardiovascular activity.Compound IVk exhibits maximum hypotensive activity (38.2 percent) and blocks the carotid occlu-sion response without affecting noradrenaline response indicating a neural (central/peripheral) origin for the hypotensive action.