78933-00-3

Basic information

• Product Name: N-[(E)-(3,5-dichlorophenyl)methylidene]-4-[4-(4-methylphenyl)piperazin-1-yl]aniline
• CAS NO: 78933-00-3
• Molecular Formula: C₂₄H₂₃Cl₂N₃
• Molecular Weight: 424.3655
• Mol File: 78933-00-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 606.9°C at 760 mmHg
• Flash Point: 320.8°C
• Density: 1.21g/cm³
• Vapor Pressure: 1.12E-14mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: N-[(E)-(3,5-dichlorophenyl)methylidene]-4-[4-(4-methylphenyl)piperazin-1-yl]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(E)-(3,5-dichlorophenyl)methylidene]-4-[4-(4-methylphenyl)piperazin-1-yl]aniline(78933-00-3)
• EPA Substance Registry System: N-[(E)-(3,5-dichlorophenyl)methylidene]-4-[4-(4-methylphenyl)piperazin-1-yl]aniline(78933-00-3)

Safety Data

• Hazardous Substances Data: 78933-00-3(Hazardous Substances Data)

Upstream product

• 16263-98-2 1-(p-Nitrophenyl)-4-(p-tolyl)piperazine 
• 100-00-5 4-chlorobenzonitrile 
• 39593-08-3 (4-methylphenyl)piperazine 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 68944-99-0 4-(4-p-tolyl-piperazin-1-yl)-phenylamine 

Downstream Products

• 78933-12-7 (3,5-Dichloro-benzyl)-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 

Relevant articles and documents

Compounds Acting on CVS : Part I - Synthesis of 1-(p-Substituted-benzylaminophenyl)-4-arylpiperazines

1-(p-Nitrophenyl)-4-arylpiperazines (II), prepared by the reaction of various arylpiperazines with p-chloronitrobenzene, on reduction with Raney nickel give the corresponding 1-(p-aminophenyl)-4-arylpiperazines (III) which are converted into 1-(p-arylideneaminophenyl)-4-arylpiperazines (IV) by condensation with appropriate araldehydes.Reduction of IV with Pd/C im DMF furnishes the title compounds.Some of these compounds have been found to possess marked cardiovascular activity.Compound IVk exhibits maximum hypotensive activity (38.2 percent) and blocks the carotid occlu-sion response without affecting noradrenaline response indicating a neural (central/peripheral) origin for the hypotensive action.