16263-98-2

Upstream product

• 39593-08-3 (4-methylphenyl)piperazine 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 73518-48-6 2-{[4-(4-p-tolyl-piperazin-1-yl)-phenylimino]-methyl}-phenol 
• 78933-13-8 (4,5-Dimethoxy-2-nitro-benzyl)-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 
• 78933-01-4 [1-(4,5-Dimethoxy-2-nitro-phenyl)-meth-(E)-ylidene]-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 
• 78933-10-5 (2-Methoxy-benzyl)-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 
• 78933-12-7 (3,5-Dichloro-benzyl)-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 
• 78933-11-6 2-{[4-(4-p-Tolyl-piperazin-1-yl)-phenylamino]-methyl}-phenol 
• 78933-00-3 [1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 
• 78932-99-7 [1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 
• 68944-99-0 4-(4-p-tolyl-piperazin-1-yl)-phenylamine 

Relevant academic research and scientific papers

Compounds Acting on CVS : Part I - Synthesis of 1-(p-Substituted-benzylaminophenyl)-4-arylpiperazines

1-(p-Nitrophenyl)-4-arylpiperazines (II), prepared by the reaction of various arylpiperazines with p-chloronitrobenzene, on reduction with Raney nickel give the corresponding 1-(p-aminophenyl)-4-arylpiperazines (III) which are converted into 1-(p-arylideneaminophenyl)-4-arylpiperazines (IV) by condensation with appropriate araldehydes.Reduction of IV with Pd/C im DMF furnishes the title compounds.Some of these compounds have been found to possess marked cardiovascular activity.Compound IVk exhibits maximum hypotensive activity (38.2 percent) and blocks the carotid occlu-sion response without affecting noradrenaline response indicating a neural (central/peripheral) origin for the hypotensive action.

New indolic hypotensive agents.

Seven substituted piperazino indoles were synthesized by the condensation of substituted piperazines with substituted indole-3-aldehyde, and evaluated for hypotensive activity. Only compound 2 exhibited promising hypotensive activity.