78933-01-4

Upstream product

• 20357-25-9 6-nitroveratraldehyde 
• 68944-99-0 4-(4-p-tolyl-piperazin-1-yl)-phenylamine 
• 16263-98-2 1-(p-Nitrophenyl)-4-(p-tolyl)piperazine 
• 100-00-5 4-chlorobenzonitrile 
• 39593-08-3 (4-methylphenyl)piperazine 

Downstream Products

• 78933-13-8 (4,5-Dimethoxy-2-nitro-benzyl)-[4-(4-p-tolyl-piperazin-1-yl)-phenyl]-amine 

Relevant academic research and scientific papers

Compounds Acting on CVS : Part I - Synthesis of 1-(p-Substituted-benzylaminophenyl)-4-arylpiperazines

1-(p-Nitrophenyl)-4-arylpiperazines (II), prepared by the reaction of various arylpiperazines with p-chloronitrobenzene, on reduction with Raney nickel give the corresponding 1-(p-aminophenyl)-4-arylpiperazines (III) which are converted into 1-(p-arylideneaminophenyl)-4-arylpiperazines (IV) by condensation with appropriate araldehydes.Reduction of IV with Pd/C im DMF furnishes the title compounds.Some of these compounds have been found to possess marked cardiovascular activity.Compound IVk exhibits maximum hypotensive activity (38.2 percent) and blocks the carotid occlu-sion response without affecting noradrenaline response indicating a neural (central/peripheral) origin for the hypotensive action.