789460-77-1

Basic information

• Product Name: B-Cycloheyl-dl-alamin-methyl ester
• Synonyms: B-Cycloheyl-dl-alamin-methyl ester;methyl 2-amino-3-cyclohexylpropanoate;METHYL 2-AMINO-3-CYCLOHEXYLPROPANOATE(WXG03206)
• CAS NO: 789460-77-1
• Molecular Formula: C10H19NO2
• Molecular Weight: 185.265
• Mol File: 789460-77-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: B-Cycloheyl-dl-alamin-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: B-Cycloheyl-dl-alamin-methyl ester(789460-77-1)
• EPA Substance Registry System: B-Cycloheyl-dl-alamin-methyl ester(789460-77-1)

Safety Data

• Hazardous Substances Data: 789460-77-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 58717-02-5 3-cyclohexyl-D-alanine 
• 127095-92-5 N-tert-butoxycarbonyl-D-cyclohexylalanine 
• 195877-59-9 methyl (R)-2-((tert-butoxycarbonyl)amino)-3-cyclohexylpropanoate 
• 5962-91-4 3-cyclohexyl-2-oxo-propionic acid 
• 17193-39-4 methyl 3-cyclohexyl-L-alaninate hydrochloride 
• 27527-05-5 L-cyclohexylalanine 
• 63-91-2 L-phenylalanine 
• 219916-56-0 (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione 
• 407578-45-4 (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione 

Relevant articles and documents

SMALL-MOLECULE PI5P4K ALPHA/BETA INHIBITORS AND METHODS OF TREATMENT USING SAME

The present invention relates to the discovery of novel 2-amino-dihydropteridinone compounds and analogues thereof capable of inhibiting phosphatidylinositol phosphate kinases. In certain embodiments, the compounds of the invention can be used to treat p5

Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist

Our previous studies identified an Fmoc-(S,R)-tryptophan-containing dipeptide derivative, 1, which selectively inhibited neutrophil elastase release induced by formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) in human neutrophils. In an attempt to improve pharmacological activity, a series of tryptophan-containing dipeptides were synthesized and their pharmacological activities were investigated in human neutrophils. Of these, five compounds 3, 6, 19a, 24a, and 24b exhibited potent and dual inhibitory effects on FMLP-induced superoxide anion (O2-) generation and neutrophil elastase release in neutrophils with IC50 values of 0.23/0.60, 1.88/2.47, 1.87/3.60, 0.12/0.37, and 1.32/1.03 μM, respectively. Further studies indicated that inhibition of superoxide production in human neutrophils by these dipeptides was associated with the selective inhibition of formyl peptide receptor 1 (FPR1). Furthermore, the results of structure-activity relationship studies concluded that the fragment N-benzoyl-Trp-Phe-OMe (3) was most suitable as a core structure for interaction with FPR1, and may be approved as a lead for the development of new drugs in the treatment of neutrophilic inflammatory diseases. As some of the synthesized compounds exhibited separable conformational isomers, and showed diverse bioactivities, the conformation analysis of these compounds is also discussed herein. The Royal Society of Chemistry 2013.

Conjugate additions of organocuprates to a 3-methylene-6-isopropyldiketopiperazine acceptor for the asymmetric synthesis of homochiral α-amino acids

Addition of a range of organocuprates to (S)-N,N′-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2, 5-dione 8 affords cis-3-isopropyl-6-alkyldiketopiperazines in excellent yield and >95% de. Subsequent deprotection and hydrolysis of these cis-3-isopropyl-6-alkyldiketopiperazines affords homochiral (S)-α-amino acids in excellent yield.