78959-41-8Relevant academic research and scientific papers
Potential Diuretics: Part I - Synthesis of Some Substituted 2,4-Dihydro-1-oxo/thioxotriazolobenzoxazines, Novel Diuretic Agents
Shridhar, D. R.,Jogibhukta, M.,Krishnan, V. S. H.,Joshi, P. P.,Naidu, M. U. R.,et al.
, p. 1279 - 1283 (2007/10/02)
Several compounds (V) derived from 2,4-dihydro-1-oxobenzoxazine and some of their 1-thioxo analogues (VI) have been synthesized and evaluated for their diuretic activity in rats.Compound Vg is the most potent member of this series with 250percent urine output of the saline control at 1 mg/kg dose.The pattern of excretion of electrolytes is similar to that of the hydrochlorothiazide at the same dose.Furthermore, its diuretic activity is very much dose-dependent over a wide range of doses (1.0-32.0 mg/kg).
Synthesis and Biological Activity of Some 2H-1,4-Benzothiazin-3-yl- and 2H-1,4-Benzoxazin-3-yl-hydrazides
Shridhar, D. R.,Jogibhukta, M.,Joshi, P. P,Vishwakarma, L. C.,Narayan, G. K. A. S. S.,et al.
, p. 474 - 476 (2007/10/02)
A series of 2H-1,4-benzothiazin-3-yl- and 2H-1,4-benzoxazin-3-yl-hydrazides (IV-VI; 1-41) have been synthesised and subjected to a wide range of biological screening which includes antiinflammatory, antibacterial, antimycobacterial, antifungal and anthelmintic testing.In the preliminary screening, several compounds in this series are found to possess promising antiinflammatory activity against carrageenin-induced oedema in rats, 40 being the most active member of the series showing 53.21percent inhibition at 200 mg/kg (p.o.) dose.Compound 41 displays significant antitubercular activity in vitro against Mycobacterium tuberculosis H37Rv as well as against INH and streptomycin resistant strains 10(N)-1> of M. tuberculosis.None of the compounds shows any noteworthy antibacterial, antifungal and anthelmintic activities.
