78994-24-8

Usage

Uses

Used in Contraceptive Applications:
Ormeloxifene is used as an oral contraceptive for the prevention of pregnancy. It works by binding to estrogen receptors in the uterus, reducing the proliferation of endometrial tissue and thus preventing fertilization.
Used in Gynecological Applications:
Ormeloxifene is used for the management of dysfunctional uterine bleeding. It helps regulate menstrual cycles and reduces excessive bleeding by modulating the estrogenic effects on the endometrium.
Used in Oncology:
Ormeloxifene is used as an anti-cancer agent, particularly in the prevention of the growth and spread of breast cancer cells. Its selective estrogen receptor modulation properties allow it to target cancer cells while minimizing effects on healthy cells.
Used in Neurodegenerative Disease Treatment:
Ormeloxifene is used for its neuroprotective effects and may be beneficial in the treatment of neurodegenerative diseases. Its ability to modulate estrogen receptors in the brain may help protect neurons and slow down disease progression.

InChI:InChI=1/C30H35NO3/c1-30(2)29(23-9-5-4-6-10-23)28(26-16-15-25(32-3)21-27(26)34-30)22-11-13-24(14-12-22)33-20-19-31-17-7-8-18-31/h4-6,9-16,21,28-29H,7-8,17-20H2,1-3H3/t28-,29+/m0/s1

Upstream product

• 213844-39-4 7-methoxy-2,2-dimethy-3-phenyl-2H-chromene 
• 103150-29-4 trans-1-[2-[4-(7-methoxy-2,2-dimethyl-3-phenyl-3,4-dihydro-2H-1-benzopyran-4-yl)phenoxy]ethyl]pyrrolidine hydrochloride 

Relevant academic research and scientific papers

Studies in Antifertility Agents. 50. Stereoselective Binding of d- and l-Centchromans to Estrogen Receptors and Their Antifertility Activity

Centchroman -7-methoxychroman hydrochloride>, an antifertility agent under clinical evaluation, has been resolved into its optical enantiomers.The cytosol estrogen receptor binding affinity and estrogenic, antiestrogenic and antiimplantation activities of the two enantiomers have been determined.The enantiomers display a 7-fold difference in receptor affinity, and a corresponding difference in stimulation of the uterine growth and antiimplantation activity was observed in rats.

AN IMPROVED PROCESS FOR THE PREPARATION OF TRANS 3,4- DIARYLCHROMAN AND THEIR DERIVATIVES

The invention describes an improved and advantageous process of preparation of trans 3,4-diarylchroman and similar derivatives there of, useful as anti-fertility, anti-osteoporotic and breast cancer drugs. Condensation of arenes with 2,2- dialkyl-3-aryl c

Process for the preparation of (-)-3,4-trans-diarylchromans

Disclosed is a process for preparing (-)-3,4-trans-diarylchromans of formula I STR1 wherein R1, R2, R3, R4 and R5 are as defined in the specification. This process involves reacting a (+,-)-3,4-cis-diarylchroman with a chiral acid in an inert organic solvent to obtain the chiral acid salt of the (-)-3,4-cis enantiomer in crystalline form, subjecting the crystalline salt to hydrolysis, and rearranging the (-)-3,4-cis enantiomer to the (-)-3,4-trans enantiomer with a strong base in an inert aprotic solvent.