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78994-24-8

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  • (- )-1-(2-(p-(trans-7-Methoxy-2,2-dimethyl-3-phenyl-4-chromanyl)phenoxy)ethyl)pyrrolidine

    Cas No: 78994-24-8

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78994-24-8 Usage

General Description

Ormeloxifene, also known as Centchroman, is a non-hormonal, selective estrogen receptor modulator (SERM) that is used as an oral contraceptive and for the management of dysfunctional uterine bleeding. It works by binding to the estrogen receptors in the uterus, thereby reducing the proliferation of the endometrial tissue. Ormeloxifene has also been found to have anti-cancer properties, particularly in preventing the growth and spread of breast cancer cells. Additionally, it has been shown to have neuroprotective effects and may be beneficial in the treatment of neurodegenerative diseases. Ormeloxifene is well-tolerated and offers a safer alternative to hormonal contraceptives, with minimal side effects and a lower risk of thromboembolic events.

Check Digit Verification of cas no

The CAS Registry Mumber 78994-24-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,9,9 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 78994-24:
(7*7)+(6*8)+(5*9)+(4*9)+(3*4)+(2*2)+(1*4)=198
198 % 10 = 8
So 78994-24-8 is a valid CAS Registry Number.
InChI:InChI=1/C30H35NO3/c1-30(2)29(23-9-5-4-6-10-23)28(26-16-15-25(32-3)21-27(26)34-30)22-11-13-24(14-12-22)33-20-19-31-17-7-8-18-31/h4-6,9-16,21,28-29H,7-8,17-20H2,1-3H3/t28-,29+/m0/s1

78994-24-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-{4-[(3S,4S)-7-Methoxy-2,2-dimethyl-3-phenyl-3,4-dihydro-2H-c hromen-4-yl]phenoxy}ethyl)pyrrolidine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:78994-24-8 SDS

78994-24-8Downstream Products

78994-24-8Relevant articles and documents

Studies in Antifertility Agents. 50. Stereoselective Binding of d- and l-Centchromans to Estrogen Receptors and Their Antifertility Activity

Salman, M.,Ray, Suprabhat,Anand, Nitya,Agarwal, A. K.,Singh, M. M.,et al.

, p. 1801 - 1803 (1986)

Centchroman -7-methoxychroman hydrochloride>, an antifertility agent under clinical evaluation, has been resolved into its optical enantiomers.The cytosol estrogen receptor binding affinity and estrogenic, antiestrogenic and antiimplantation activities of the two enantiomers have been determined.The enantiomers display a 7-fold difference in receptor affinity, and a corresponding difference in stimulation of the uterine growth and antiimplantation activity was observed in rats.

Process for the preparation of (-)-3,4-trans-diarylchromans

-

, (2008/06/13)

Disclosed is a process for preparing (-)-3,4-trans-diarylchromans of formula I STR1 wherein R1, R2, R3, R4 and R5 are as defined in the specification. This process involves reacting a (+,-)-3,4-cis-diarylchroman with a chiral acid in an inert organic solvent to obtain the chiral acid salt of the (-)-3,4-cis enantiomer in crystalline form, subjecting the crystalline salt to hydrolysis, and rearranging the (-)-3,4-cis enantiomer to the (-)-3,4-trans enantiomer with a strong base in an inert aprotic solvent.

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