Studies in Antifertility Agents. 50. Stereoselective Binding of d- and l-Centchromans to Estrogen Receptors and Their Antifertility Activity

DOI: 10.1021/jm00159a044

Source and publish data:

Journal of Medicinal Chemistry p. 1801 - 1803 (1986)

Update date:2022-08-28

Topics:

Authors:

Salman, M.

Ray, Suprabhat

Anand, Nitya

Agarwal, A. K.

Singh, M. M.

et al. et al.

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Article abstract of DOI:10.1021/jm00159a044

Centchroman -7-methoxychroman hydrochloride>, an antifertility agent under clinical evaluation, has been resolved into its optical enantiomers.The cytosol estrogen receptor binding affinity and estrogenic, antiestrogenic and antiimplantation activities of the two enantiomers have been determined.The enantiomers display a 7-fold difference in receptor affinity, and a corresponding difference in stimulation of the uterine growth and antiimplantation activity was observed in rats.

Full text of DOI:10.1021/jm00159a044

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