790-44-3Relevant academic research and scientific papers
Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides
Judge, Vikramjeet,Ahuja, Munish,Narasimhan, Balasubramanian,Sriram, Dharmarajan,Yogeeswari, Perumal,De Clercq, Erik,Pannecouque, Christophe,Balzarini, Jan
, p. 1935 - 1952,18 (2020/07/30)
A series of isonicotinic acid-1-(substituted phenyl)-ethylidene/ cycloheptylidene hydrazide derivatives (1-12) was tested for their, in vitro antimycobacterial activity against Mycobacterium tuberculosis, and compound 2 was found to be more active than isoniazid. The antiviral screening results indicated that none of the tested compounds was active against a broad variety of DNA and RNA viruses at subtoxic concentrations, except compounds 8 and 10 that proved to be active against DNA viruses at concentrations close to their cytostatic potential. The synthesized compounds were also screened for their antimicrobial potential against S. aureus, B. subtilis, E. coli, C. albicans and A. niger, and the results indicated that compounds having Br, OCH3 and Cl groups were highly active. The multi-target QSAR models indicated the importance of lipophilic (log P) and topological parameters (3vv) in describing the antimicrobial activity.
Synthesis, characterization of (E)-N'-(substituted-benzylidene) isonicotinohydrazide derivatives as potent antitubercular agents
Malhotra, Manav,Sharma, Rajiv,Monga, Vikramdeep,Deep, Aakash,Sahu, Kapendra,Samad, Abdul
experimental part, p. 575 - 579 (2012/06/01)
A series of 19 isonicotinic acid hydrazide derivatives has been synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using alamar blue susceptibility test. The synthesized comp
