790288-81-2

Basic information

• Product Name: N-(3-(trifluoromethyl)benzyl)picolinamide
• Synonyms: N-(3-(trifluoromethyl)benzyl)picolinamide
• CAS NO: 790288-81-2
• Molecular Weight: 280.249
• Mol File: 790288-81-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3-(trifluoromethyl)benzyl)picolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(trifluoromethyl)benzyl)picolinamide(790288-81-2)
• EPA Substance Registry System: N-(3-(trifluoromethyl)benzyl)picolinamide(790288-81-2)

Safety Data

• Hazardous Substances Data: 790288-81-2(Hazardous Substances Data)

Upstream product

• 98-98-6 2-Picolinic acid 
• 2740-83-2 3-(TRIFLUOROMETHYL)BENZYLAMINE 

Downstream Products

• 1380678-51-2 C₂₀H₁₉F₃N₂O 
• 1380678-75-0 C₂₅H₃₁F₃N₂OSi 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 1332481-63-6 C₁₇H₁₇F₃N₂O 

Relevant articles and documents

Cobalt-Catalyzed ortho-C?H Functionalization/Alkyne Annulation of Benzylamine Derivatives: Access to Dihydroisoquinolines

A practical picolinamide-directed C?H functionalization/alkyne annulation of benzylamine derivatives enabling access to the previously elusive 1,4-dihydroisoquinoline skeleton was developed using molecular O2 as the sole oxidant and Co(OAc)2 as precatalyst. The method is compatible with both internal and terminal alkynes and shows high versatility and functional-group tolerance. Furthermore, full preservation of enantiopurity is observed when using non-racemic α-substituted benzylamine derivatives. Kinetic analysis of the reagents and catalyst, labeling experiments, and the isolation and identification of catalytically competent Co-complexes revealed important insights about the mechanism.