79043-73-5

Upstream product

• 79043-74-6 (S)-3-((S)-4-Benzyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-tert-butoxycarbonylamino-propionic acid benzyl ester 
• 79043-75-7 N-(tert-Butoxycarbonyl)-β-benzyl-L-aspartyl-Δ^Z-phenylalanine azlactone 
• 68763-45-1 N-(tert-Butoxycarbonyl)-β-benzyl-L-aspartyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 79043-76-8 N-(tert-Butoxycarbonyl)-β-benzyl-L-aspartyl-Δ^Z-phenylalanine methyl ester 

Relevant academic research and scientific papers

Process for preparing α-L-aspartyl-L-phenylalanine methyl ester

A process for preparing α-L-aspartyl-L-phenylalanine methyl ester: STR1 in which: (a) the compound methyl N(α-L-aspartyl)α-aminocinnamate, protected at the nitrogen, of formula: STR2 where R is a protector group at the nitrogen, is subjected to hydrogenation at the olefin bond by means of gaseous hydrogen in the presence of a hydrogenation catalyst, to give the compound of formula: STR3 where R has the aforesaid meaning, in the form of a mixture of α-L-aspartyl-L-phenylalanine methyl ester protected at the nitrogen, and α-L-aspartyl-D-phenylalanine methyl ester protected at the nitrogen; (b) the protector group is removed from the α-L-aspartyl-L-phenylalanine and α-L-aspartyl-D-phenylalanine methyl esters protected at the nitrogen; (c) the α-L-aspartyl-L-phenylalanine methyl ester is separated and recovered from the deprotection reaction product.