68763-45-1

Usage

Uses

Used in Organic Chemistry:
BOC-ASP(OBZL)-PHE-OH is used as a building block for the synthesis of peptides and other bioactive molecules. The protective groups on the amino acid residues allow for selective chemical reactions, ensuring that the desired parts of the molecule remain undamaged during the synthesis process.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, BOC-ASP(OBZL)-PHE-OH is utilized for the development of peptide-based drugs. BOC-ASP(OBZL)-PHE-OH's structure and protective groups facilitate the synthesis of complex peptide sequences, which can be used to create new medications with specific therapeutic properties.
Used in Research and Development:
BOC-ASP(OBZL)-PHE-OH is also used in research and development settings to study the properties and interactions of peptides and other bioactive molecules. BOC-ASP(OBZL)-PHE-OH's structure allows researchers to investigate the effects of different chemical modifications on the molecule's activity and stability, contributing to the advancement of scientific knowledge in the field of organic chemistry and biochemistry.

Upstream product

• 63-91-2 L-phenylalanine 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 106556-06-3 Boc-Asp(OBzl)-Phe-OCAM 
• 126706-44-3 Boc-Asp(OBzl)-Phe-OPac 
• 7647-01-0 hydrogenchloride 
• 26048-69-1 (S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(4-nitro-phenyl) ester 
• 150-30-1 Phenylalanine 
• 84890-97-1 (S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 79043-73-5 Dehydroaspartame 
• 79043-75-7 N-(tert-Butoxycarbonyl)-β-benzyl-L-aspartyl-Δ^Z-phenylalanine azlactone 
• 79043-76-8 N-(tert-Butoxycarbonyl)-β-benzyl-L-aspartyl-Δ^Z-phenylalanine methyl ester 
• 1147835-22-0 Boc-Asp(OBn)-Phe-Arg(Nω-NO2)-Gly-Asp(OBn)-Phe-OBn 

Relevant academic research and scientific papers

3D QSAR of novel estrogen-RGD peptide conjugates: Getting insight into structural dependence of anti-osteoporosis activity and side effect of estrogen in ERT

To explore the structural dependence of the oral potency and side effect of estrogen-RGD peptide conjugates, here six novel conjugates were prepared via introducing RGD-tetrapeptides into both 3- and 17-positions of estradiol, and introducing RGD-octapept

Selective removal of phenacyl ester group with a TBAF·xH2O-thiol system from amino acid derivatives containing benzyl or 4-nitrobenzyl ester

A facile cleavage method of phenacyl ester bonds by combined use of tetrabutylammonium fluoride hydrate (TRAF·xH2O) and 1-octanethiol was established. Benzyl and 4-nitrobenzyl esters are almost stable toward this reagent.

CHOLECYSTOKININ HEPTAPEPTIDE ANALOGUES WITH MULTIPLE MODIFICATION IN PEPTIDE CHAIN

Using solid phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr(SO3-Na+)-Met-Gly-Trp-Met-Asp-Phe-NH2) Ia and its seven analogues Ib - Ih.In the analogues Ib and Ic the Met residue in the carboxyterminal part of the molecule was substituted for L- or D-PheMe3.In the analogues Id and Ie with Phe residue substituted by L- or D-PheMe3 the Neo was inserted in the place of this Met residue and in the analogues If and Ig, in addition to PheMe3 substitution in the carboxyterminus, both Met residues were replaced for Neo.This dual substitution for Met residues was also applied in the analogue Ih with coded Phe residue in the C-terminus.

On the Use of Carboxamidomethyl Esters in the Protease-Catalyzed Peptide Synthesis

Carboxyamidomethyl esters (CAM esters) of Z-and Boc-protected alanine and phenylalanine were prepared in order to investigate their usefulness as substrates for α-chymotrypsin- and papain-catalyzed hydrolysis and peptide synthesis reactions.The easy removal of the CAM-C-protecting group under mild conditions and dependent on the enzyme specificity was demonstrated.Examples are given for the protease-catalyzed synthesis of various peptide derivatives using CAM esters as C- and N-components in aqueous-organic media.Comparatively short reaction times were observed. - Key words: Carboxyamidomethyl ester as C-protecting group; Enzymatic deprotection; Peptide synthesis; α-Chymotrypsin- and Papain-catalyzed peptide bond formation

Radioimmunoassay method for determining calcitonin and radioactive tracer for use therein

A hentriacontapeptide of the formula (I) STR1 a radioactive labeled hentriacontapeptide of the formula (I), useful in a radioimmunoassay method and a radioimmunoassay method for determining calcitonin.