111141-00-5

Basic information

• Product Name: 8-Fluoro-4-chromanone
• Synonyms: 5-fluoro-3,4-dihydro-2H-1-benzopyran-4-one;8-fluoro-2,3-dihydrochroMen-4-one;8-fluoro-3,4-dihydro-2H-1-benzopyran-4-one;8-Fluoro-4-chromanone;8-FLUORO-4-OXO-CHROMAN;8-Fluoro-2,3-dihydro-4H-chromen-4-one;8-fluorochroman-4-one
• CAS NO: 111141-00-5
• Molecular Formula: C9H7FO2
• Molecular Weight: 166.1490832
• Product Categories: Fused Ring Systems
• Mol File: 111141-00-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 84-87 °C
• Boiling Point: 279.991 °C at 760 mmHg
• Flash Point: 119.357 °C
• Appearance: /
• Density: 1.298 g/cm³
• Vapor Pressure: 0.00389mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-Fluoro-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Fluoro-4-chromanone(111141-00-5)
• EPA Substance Registry System: 8-Fluoro-4-chromanone(111141-00-5)

Safety Data

• Hazardous Substances Data: 111141-00-5(Hazardous Substances Data)

Usage

General Description

8-Fluoro-4-chromanone is a chemical compound with the molecular formula C9H7FO2. It is a derivative of chromanone, a naturally occurring compound found in plants. 8-Fluoro-4-chromanone is a synthetic chemical that is commonly used as a building block in the production of pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, such as anti-inflammatory and antioxidant properties. 8-Fluoro-4-chromanone is also used as a starting material for the synthesis of various biologically active molecules. Due to its versatile nature, 8-Fluoro-4-chromanone has potential applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C9H7FO2/c10-7-3-1-2-6-8(11)4-5-12-9(6)7/h1-3H,4-5H2

Upstream product

• 2967-72-8 3-(2-fluorophenoxy)propanoic acid 
• 111140-91-1 3-(2-fluorophenoxy)propanenitrile 
• 133077-42-6 3-(3-fluorophenoxy)propanoic acid 
• 367-12-4 2-fluorophenol 
• 844648-05-1 3-(3-fluorophenoxy)propanenitrile 
• 372-20-3 3-fluorophenol 

Downstream Products

• 911826-26-1 (R)-2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one 
• 911826-25-0 (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)-5-nitropyrimidine-2,4-diamine 
• 1026790-40-8 (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine 
• 1026790-41-9 (R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one 
• 1003887-62-4 (S)-8-fluorochroman-4-amine 
• 791043-28-2 8-fluorochroman-4-amine 
• 750571-31-4 (R)-8-fluorochroman-4-amine 

Relevant articles and documents

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The invention relates to the compounds (I) and their acids and bases salts: wherein: the dotted line indicates a double bond; X is N or C-R1 and Y is N or C-R2, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is Hydrogen or a substituent as defined in the application, or B is a (4-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, and possibly substituted as defined in the application; B not being Hydrogen when X is N and Y is C-R2; R1 is Hydrogen or a substituent as defined in the application; B and R1 cannot be simultaneously Hydrogen; R2 is Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them.

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The invention provides compounds of the formula (0), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.

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