791068-95-6

Upstream product

• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 457628-23-8 2-hydroxy-4-(trifluoromethanesulfonyloxy)benzaldehyde 
• 22532-62-3 4-bromosalicylaldehyde 

Downstream Products

• 791068-99-0 4-ethynyl-2-hydroxybenzaldehyde 
• 791068-98-9 C₂₆H₁₈O₆ 
• 791068-97-8 C₁₈H₁₀O₄ 
• 791068-96-7 C₁₆H₁₀O₄ 

Relevant academic research and scientific papers

Doubly Caged Linker for AND-Type Fluorogenic Construction of Protein/Antibody Bioconjugates and In Situ Quantification

In situ quantification of the conjugation efficiency of azide-terminated synthetic polymers/imaging probes and thiol-functionalized antibodies/proteins/peptides was enabled by a doubly caged profluorescent and heterodifunctional core molecule C1 as a self-sorting bridging unit. Orthogonal dual “click” coupling of C1 with azide- and thiol-functionalized precursors led to highly fluorescent bioconjugates, whereas single-click products remained essentially nonfluorescent. Integration with FRET processes was also possible. For the construction of antibody–probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual “click” coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody–imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells.

Fluorophore-containing conjugate, segmented copolymer, targeted drug and preparation method and application thereof

The invention provides fluorophore-containing conjugate of a structure from C1 to C3. The fluorophore-containing conjugate contains one fluorophore and two high-reaction-activity groups R1 and R2 connected on the fluorophore through a covalent bond; the fluorophore in the conjugate does not have or only has weak fluorescence emission ability at the beginning and has strong fluorescence emission ability only after the high-reaction-activity groups jointly react with corresponding molecules, so that conjugation efficiency of drug molecules and targeted molecules can be monitored in situ through infrared fluorescence emission strength, and the fluorophore-containing conjugate can be applied to target mediated drug transmission.

Fluorescent non-linear chiral polymer chemosensor bonded alternatively with 1,4-diethynyl-2,5-dioctyloxybenzene and (R,R)-salen for Zn 2+recognition

Stereoregular non-linear chiral main chain polymers 1a-b bonded alternatively with (R,R)-salen and 1,4-diethynyl-2,5-dioctyloxybenzene moieties have been synthesized using palladium catalyzed C-C cross-coupling and Schiff base formation reactions as the k

Synthesis and metalation of novel fluorescent conjugated macrocycles

(Chemical Equation Presented) Large shape-persistent conjugated macrocycles with tunable pore diameters in the nanometer regime were prepared by a simple, one-pot procedure. These new self-assembled macrocycles contain rings of 48-66 covalently bonded atoms and can bind multiple metal ions, forming soluble luminescent complexes.