791068-99-0

Upstream product

• 791068-95-6 4-trimethylsilylacetylenesalicylaldehyde 
• 22532-62-3 4-bromosalicylaldehyde 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 457628-23-8 2-hydroxy-4-(trifluoromethanesulfonyloxy)benzaldehyde 

Downstream Products

• 791068-96-7 C₁₆H₁₀O₄ 
• 791068-98-9 C₂₆H₁₈O₆ 
• 1261302-49-1 4,4'-(E)-but-1-en-3-yne-1,4-diylbis(2-hydroxybenzaldehyde) 
• 1191396-93-6 C₄₀H₄₆O₆ 
• 791068-97-8 C₁₈H₁₀O₄ 
• 1065497-18-8 C₃₆H₂₆O₈ 

Relevant academic research and scientific papers

Doubly Caged Linker for AND-Type Fluorogenic Construction of Protein/Antibody Bioconjugates and In Situ Quantification

In situ quantification of the conjugation efficiency of azide-terminated synthetic polymers/imaging probes and thiol-functionalized antibodies/proteins/peptides was enabled by a doubly caged profluorescent and heterodifunctional core molecule C1 as a self-sorting bridging unit. Orthogonal dual “click” coupling of C1 with azide- and thiol-functionalized precursors led to highly fluorescent bioconjugates, whereas single-click products remained essentially nonfluorescent. Integration with FRET processes was also possible. For the construction of antibody–probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual “click” coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody–imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells.

Fluorophore-containing conjugate, segmented copolymer, targeted drug and preparation method and application thereof

The invention provides fluorophore-containing conjugate of a structure from C1 to C3. The fluorophore-containing conjugate contains one fluorophore and two high-reaction-activity groups R1 and R2 connected on the fluorophore through a covalent bond; the fluorophore in the conjugate does not have or only has weak fluorescence emission ability at the beginning and has strong fluorescence emission ability only after the high-reaction-activity groups jointly react with corresponding molecules, so that conjugation efficiency of drug molecules and targeted molecules can be monitored in situ through infrared fluorescence emission strength, and the fluorophore-containing conjugate can be applied to target mediated drug transmission.

Fluorescent non-linear chiral polymer chemosensor bonded alternatively with 1,4-diethynyl-2,5-dioctyloxybenzene and (R,R)-salen for Zn 2+recognition

Stereoregular non-linear chiral main chain polymers 1a-b bonded alternatively with (R,R)-salen and 1,4-diethynyl-2,5-dioctyloxybenzene moieties have been synthesized using palladium catalyzed C-C cross-coupling and Schiff base formation reactions as the k

One-pot desilylation/dimerization of terminal alkynes by ruthenium and acid-promoted (RAP) catalysis

The dimerization of terminal arylalkynes promoted by the (p-cymene)ruthenium dichloride dimer/acetic acid system {[RuCl 2(p-cymene)]2/AcOH} can be performed starting from the trimethylsilylethynyl derivatives (12 substrates), deprotected in situ, to afford 1,4-disubstituted 1-en-3-ynes with high regio- and (E)-stereoselectivity, at room temperature. The extension of this unprecedented two-reaction sequence to a diyne substrate affords a fluorene-based conjugated oligomer. The reaction mixture resulting from the desylilation-dimerization process dimerizes additional aliquots of phenylacetylene. The one-pot protocol results in shorter reaction times due to the presence of acetate salts which increase the concentration of active catalytic species, in which the acetate ligand acts as base toward the bound alkyne. The ruthenium source is transformed into a new trihapto-hexa-1,3-dien-5-yn-3-yl complex, formed by metal-assisted coupling of the enyne product and the terminal alkyne, and still maintaining catalytic activity. Selectivity, endurance, medium and functional group compatibility are the key features of the catalytic system obtained from the p-cymene ruthenium dimer under the one-pot conditions.

Synthesis and metalation of novel fluorescent conjugated macrocycles

(Chemical Equation Presented) Large shape-persistent conjugated macrocycles with tunable pore diameters in the nanometer regime were prepared by a simple, one-pot procedure. These new self-assembled macrocycles contain rings of 48-66 covalently bonded atoms and can bind multiple metal ions, forming soluble luminescent complexes.