791077-90-2Relevant academic research and scientific papers
Inhibition of nucleoside transport by new analogues of 4- nitrobenzylthioinosine: Replacement of the ribose moiety by substituted benzyl groups
Tromp, Reynier A.,Van Ameijde, Susan,Pütz, Claudia,Sundermann, Corinna,Sundermann, Bernd,Von Frijtag Drabbe Künzel, Jacobien K.,Ijzerman, Adriaan P.
, p. 5441 - 5450 (2004)
4-Nitrobenzylthioinosine (NBTI, 1) is a well-known inhibitor for the nucleoside transport protein ENT1. However, its highly polar nature is unfavorable for oral absorption and/or penetration into the CNS. In the search for compounds with lower polarity th
