931430-03-4Relevant articles and documents
Synthesis of β-CF 3 Ketones through Copper/Silver Cocatalyzed Oxidative Coupling of Enol Acetates with ICH 2 CF 3
Xiong, Yi,Chen, De,Zeng, Sheng,Cheng, Chaozhihui,Wang, Pengjie,Deng, Wei,Xiang, Jiannan,Yi, Niannian
supporting information, p. 2279 - 2282 (2018/10/20)
A simple method for the synthesis of β-CF 3 ketones through copper/silver cocatalyzed oxidative coupling of enol acetates with ICH 2 CF 3 has been developed. Enol acetates were chosen as the source of carbonyl group, giving the β-CF 3 ketones in moderate yields. Control experiments imply that a radical process maybe involved in this reaction.
Copper/Silver Cocatalyzed Oxidative Coupling of Vinylarenes with ICH2CF3 or ICH2CHF2 Leading to β-CF3/CHF2-Substituted Ketones
Yi, Niannian,Zhang, Hao,Xu, Chonghui,Deng, Wei,Wang, Ruijia,Peng, Dongming,Zeng, Zebing,Xiang, Jiannan
supporting information, p. 1780 - 1783 (2016/05/19)
A novel copper/silver cocatalyzed oxidative coupling of vinylarenes with ICH2CF3 or ICH2CHF2 through a radical process has been developed. The transformation provides an attractive approach to β-CF3/CHF2-substituted ketones, with the advantages of easily available starting materials and operational simplicity.
Boron-trihalide-promoted regioselective ring-opening reactions of gem-difluorocyclopropyl ketones
Yang, Tang-Po,Li, Qiang,Lin, Jin-Hong,Xiao, Ji-Chang
supporting information, p. 1077 - 1079 (2014/01/17)
Boron trihalide-promoted ring-opening reactions of gem-difluorocyclopropyl ketones to give the corresponding β-trifluoromethyl ketones and β-halodifluoromethyl ketones were described. It was found that boron trihalides act as both Lewis acids and nucleophiles and the proximal bond prefers to cleave in this transformation.
AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE
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Page/Page column 71, (2009/03/07)
The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
AMINO-5-[4-(DIFLUOROMETHOXY)-PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE
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Page/Page column 21; 22, (2008/06/13)
The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.