791642-67-6

Basic information

• Product Name: 1-Chloro-2-iodo-3-methoxy-benzene
• Synonyms: 1-Chloro-2-iodo-3-methoxy-benzene
• CAS NO: 791642-67-6
• Molecular Formula: C7H6ClIO
• Molecular Weight: 268.482
• Mol File: 791642-67-6.mol

Chemical Properties

• CAS DataBase Reference: 1-Chloro-2-iodo-3-methoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2-iodo-3-methoxy-benzene(791642-67-6)
• EPA Substance Registry System: 1-Chloro-2-iodo-3-methoxy-benzene(791642-67-6)

Safety Data

• Hazardous Substances Data: 791642-67-6(Hazardous Substances Data)

Usage

Type of compound

Substituted benzene derivative

Chlorine atom position

1

Iodine atom position

2

Methoxy group position

3

Primary use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Additional use

Reagent in organic synthesis for introducing specific functional groups

Potential applications

Production of specialty polymers and advanced materials in materials science

Hazardous nature

Yes, may pose risks to human health and the environment

Handling precautions

Handle with care and follow safety guidelines

Upstream product

• 2845-89-8 1-chloro-3-methoxy-benzene 
• 5472-99-1 3-chloro-2-nitroanisole 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 
• 858854-82-7 3-chloro-2-iodo-phenol 
• 74-88-4 methyl iodide 
• 158966-62-2 6-chloro-o-anisidine 

Downstream Products

• 945470-08-6 1-chloro-2-(1-hexynyl)-3-methoxybenzene 
• 945470-09-7 1-chloro-3-methoxy-2-(1-pentynyl)benzene 
• 945470-36-0 2-but-1-ynyl-1-chloro-3-methoxybenzene 
• 945470-07-5 3-chloro-2-phenylethynylanisole 
• 1287791-66-5 2-(3-chloro-2-iodophenoxy)-2-methylpropanamide 
• 1287792-07-7 2-butyl-4-chloro-3-(phenylthio)-1H-indole 
• 1244651-34-0 N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide 
• 1244652-07-0 4-chloro-2-(3-chlorophenyl)-1H-indole 
• 1244651-54-4 N-(3-chloro-2-(2-(trimethylsilyl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-49-7 N-(3-chloro-2-(hept-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-45-3 N-(3-chloro-2-(hex-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 70237-25-1 3-chloro-2-iodobenzenamine 
• 108-42-9 3-chloro-aniline 
• 25235-85-2 4-chloro-1H-indole 

Relevant articles and documents

Combined directed ortho-zincation and palladiumcatalyzed strategies: Synthesis of 4,n-dimethoxysubstituted benzo[b]furans

A new route to regioselectively dialkoxy-functionalized benzo[b]furan derivatives has been developed from 3-halo-2-iodoanisoles bearing an additional methoxy group, which have been accessed through an ortho-zincation/iodination reaction. Two palladiumcata

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.

Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: Application to the preparation of indole inhibitors of phospholipase A 2

(Chemical Equation Presented) An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting materials such as 3-halophenols and 3-chloroanisole. Directed ortho-metalation followed by two pallad

The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors

Elevation of glycine levels by inhibition of the glycine transporter-1 (GlyT-1) and activation of the NMDA receptor is a potential strategy for the treatment of schizophrenia. A novel series of 2-arylsulfanylphenyl-1-oxyalkyl amino acids have been identif

AROMATIC OXYPHENYL AND AROMATIC SYLFANYLPHENYL DERIVATIVES

The present invention relates to compounds of formula I wherein the substituents are as defined below. The compounds of formula I are useful for the treatment of diseases such as schizophrenia, including both the positive and the negative symptoms of schizophrenia and other psychoses.