70237-25-1

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2-iodoaniline is used as a key intermediate in the synthesis of indolyl benzoic acid derivatives, which serve as NURR-1 activators. These activators are crucial for the development of treatments targeting Parkinson's disease, a neurodegenerative disorder affecting movement and motor control. By modulating the activity of the NURR-1 receptor, these indolyl benzoic acid derivatives may help alleviate the symptoms and slow the progression of Parkinson's disease.

InChI:InChI=1/C6H5ClIN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2

Upstream product

• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 
• 1244651-34-0 N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide 
• 1287791-66-5 2-(3-chloro-2-iodophenoxy)-2-methylpropanamide 
• 769-11-9 2-chloro-6-nitroaniline 
• 121-73-3 3-Nitrochlorobenzene 
• 108-42-9 3-chloro-aniline 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 791642-67-6 1-chloro-2-iodo-3-methoxybenzene 
• 858854-82-7 3-chloro-2-iodo-phenol 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 32337-97-6 1-chloro-2-iodo-3-nitrobenzene 
• 603-86-1 2-chloro-6-nitrophenol 

Downstream Products

• 72995-15-4 5-chloro-3,4-dihydro-2(1H)-quinolinone 
• 882023-24-7 2-oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile 
• 1849-73-6 2-mercapto-7-chlorobenzothiazole 

Relevant academic research and scientific papers

ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

Remarkable switch in the regiochemistry of the iodination of anilines by N-iodosuccinimide: Synthesis of 1,2-dichloro-3,4-diiodobenzene

Direct iodination of anilines by NIS in polar solvents (such as DMSO) affords p-iodinated products with up to >99% regioselectivity. Switching to less polar solvents (such as benzene) in the presence of AcOH inverts this outcome toward dramatically increased or preferential generation of the o-isomers, also with up to >99% regioselectivity. This finding was exploited in the synthesis of 1,2-dichloro-3,4-diiodobenzene. Georg Thieme Verlag Stuttgart - New York.

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Efficient total synthesis of (-)-cis-clavicipitic acid

An efficient total synthesis of (-)-cis-clavicipitic acid has been achieved in seven linear steps (42% overall yield) from the known compound 6. The present synthesis features a palladium-catalyzed indole synthesis to provide the optically pure 4-chlorotr

Compounds and Uses Thereof

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of anxiety disorders, cognitive disorders, and/or mood disorders.