79205-14-4

Upstream product

• 616-43-3 3-methylpyrrole 
• 1989-53-3 2,6-dimethoxybenzoyl chloride 
• 79205-16-6 ethyl 5-(2',6'-dimethoxybenzoyl)-4-methylpyrrole-3-carboxylate 
• 2199-49-7 ethyl 4-methylpyrrole-3-carboxylate 
• 79205-18-8 5-(2',6'-dimethoxybenzoyl)-4-methylpyrrole-3-carboxylic acid 

Downstream Products

• 79205-24-6 2-(2',6'-dihydroxybenzoyl)-3-phenylpyrrole O,O-diacetate 
• 79205-25-7 4-methylpyoluteorin O,O-diacetate 
• 79205-23-5 2-(2',6'-dihydroxybenzoyl)-3-methylpyrrole O,O-diacetate 
• 79205-21-3 2-(2',6'-dihydroxybenzoyl)-3-methylpyrrole 

Relevant academic research and scientific papers

Pyoluteorin Derivatives. II. Synthetic Approaches to Pyrrole Ring Substituted Pyoluteorins (1)

A method for the regiospecific synthesis of 3-substituted 2-aroylpyrroles is described.These pyrroles, which are structurally related to the naturally occuring antibiotic pyoluteorin, are prepared by a Friedel-Crafts aroylation of 4-substituted pyrrole-3-carboxylic acid esters with 2,6-dimethoxybenzoyl chloride.The carboalkoxy group is then removed by hydrolysis and decarboxylation to produce isomerically pure 3-substituted-2-(2',6'-dimethoxybenzoyl)pyrroles (5 and 13).Conversion of these pyrroles into pyoluteorin-like coumpounds led to some unexpected products which arise from facile cleavage of the dihydroxybenzoyl portion of the molecules during chlorination.