2199-49-7Relevant articles and documents
Propentdyopents and Related Compounds. Part 2. The Z E Photoisomerisation of Pyrromethenone Systems
Bonnett, Raymond,Hamzetash, Dariush,Valles, Maria Asuncion
, p. 1383 - 1388 (1987)
The Z E photoisomerisation of four α-unsubstituted pyrromethenones which are potential precursors of alkanol-propentdyopent adducts is studied using a direct n.m.r. spectroscopic approach in CD3OD-CDCl3.Chemical-shift assignments are made with the help of n.O.e. and decoupling experiments.For the polyalkylpyrromethenones the photostationary state contains ca. 25percent of the E isomer: a system with a β-ethoxycarbonyl group leads to 43percent E isomer at photoequilibrium.The E isomers can be manipulated in solution without appreciable change, but thermodynamic equilibration to the Z isomer (ca. 99percent) occurs on dry silica.A similar photoisomerisation of (4Z,15Z)-bilirubin IIIα in ND3-CD3OD leads to a photoequilibrated mixture containing 16percent of (4E,15Z)-bilirubin IIIα.
Synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties
Jin, Yun-Zhou,Fu, Da-Xu,Ma, Nan,Li, Zhan-Cheng,Liu, Quan-Hai,Xiao, Lin,Zhang, Rong-Hua
experimental part, p. 9368 - 9385 (2012/01/05)
Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethylamino) ethylcarbamoyl group as a substituent at the C-4' position of the pyrrole enhanced the antitumor activities notably. IC 50 values as low as 0.32, 0.67, 1.19 and 1.22 μM were achieved against non-small cell lung cancer (A549), oral epithelial (KB), melanoma (K111) and large cell lung cancer cell lines (NCI-H460), respectively.
PROTON PUMP INHIBITORS
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, (2008/06/13)
A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.
