79205-59-7Relevant academic research and scientific papers
STEREOSPECIFIC SYNTHESIS OF 2-AMINO-3-FLUORONITRILES. PREPARATION OF β-FLUORO-α-AMINO ACID AND ESTERS
Ayi, A. I.,Guedj, R.
, p. 137 - 152 (1984)
The synthesis of some 2-amino-3-fluoro-nitriles and 2-amino-3-fluoro-acids and their esters have been achieved by means of a Strecker-type reaction.The method involved the action of amines with 3-fluoro-2-hydroxy-nitriles followed by acid solvolysis.The f
NOUVELLE VOIE DE SYNTHESE D'ACIDES AMINES MONOFLUORES
Ayi, A. I.,Remli, M.,Guedj, R.
, p. 1505 - 1508 (2007/10/02)
Ring opening of the glycidonitriles (IIa-e) by HF/pyridine leads to the fluorocyanohydrins (IIIa-e).Treatment of the nitriles (IIIa-e) with ammonia in methanol gives the α-amino-β-fluoro nitriles (IVa-e) which upon acidic hydrolysis afford the β-fluoro-α-
