79208-80-3Relevant academic research and scientific papers
Cyclisation indolique selon Bischler en presence d'acides de Lewis
Galons, Herve,Girardeau, Jean-Francois,Farnoux, Claude Combet,Miocque, Marcel
, p. 561 - 564 (2007/10/02)
In a comparative study of various catalysts (hydrochloric acid, Lewis acids) in the Bischler cyclization of α-aminoketones to indoles, aluminium chloride appears as the most active catalyst.Isomerization of β to α-indoles can be observed by raising the reaction temperature.The mechanism seems different from the one frequently suggested by most authors, since it does not affect intermediate aminoketones but indoles.
