937-38-2

Basic information

• Product Name: 1-Chloro-3-Phenylacetone
• Synonyms: 1-chloro-3-phenyl-propan-2-one;1-chloro-3-phenylpropan-2-one;2-Propanone, 1-chloro-3-phenyl-
• CAS NO: 937-38-2
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.6202
• Mol File: 937-38-2.mol
• Article Data: 23

Chemical Properties

• Melting Point: 72-73 °C
• Boiling Point: 244.7 °C at 760 mmHg
• Flash Point: 119.6 °C
• Appearance: /
• Density: 1.145 g/cm³
• Vapor Pressure: 0.0299mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Chloro-3-Phenylacetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3-Phenylacetone(937-38-2)
• EPA Substance Registry System: 1-Chloro-3-Phenylacetone(937-38-2)

Safety Data

• Hazardous Substances Data: 937-38-2(Hazardous Substances Data)

Usage

General Description

1-Chloro-3-Phenylacetone, also known as bmk glycidate, is a chemical compound that is commonly used in the production of illegal drugs such as methamphetamine and MDMA. It is a precursor chemical that is often synthesized from phenylacetone and hydrochloric acid, and is subsequently used in the synthesis of these illicit substances. Due to its potential for misuse and abuse, 1-Chloro-3-Phenylacetone is classified as a controlled substance in many countries and its production, distribution, and use are strictly regulated. The compound has no known legitimate uses and is largely associated with the illegal drug trade.

InChI:InChI=1/C9H9ClO/c10-7-9(11)6-8-4-2-1-3-5-8/h1-5H,6-7H2

Upstream product

• 103-80-0 phenylacetyl chloride 
• 79-04-9 chloroacetyl chloride 
• 6921-34-2 benzylmagnesium chloride 
• 20485-53-4 1-chloro-3-diazopropan-2-one 
• 71-43-2 benzene 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 103-79-7 1-phenyl-acetone 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 3173-53-3 Cyclohexyl isocyanate 
• 23605-23-4 2-Chloro-N-cyclohexylacetamide 
• 4392-27-2 trans-2-(chloromethyl)-3-phenyloxirane 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 62673-31-8 benzyl(bromo)zinc 

Downstream Products

• 103-25-3 3-phenylpropanoic acid methyl ester 
• 86521-18-8 3-Ethylthio-1-phenyl-2-propanone 
• 36960-03-9 2-oxo-3-phenylpropyl acetate 
• 726-26-1 phenyl 3-phenylpropanoate 
• 27839-94-7 1-phenyl-3-(phenylsulfonyl)propan-2-one 
• 4982-08-5 1-hydroxy-3-phenylpropan-2-one 
• 121426-36-6 2,5-dibenzyl-[1,4]dithiane-2,5-diol 
• 7496-56-2 2-amino-4-benzylthiazole 
• 94378-12-8 N-[1-(4-benzyl-thiazol-2-yl)-ethyl]-benzamide 
• 92102-02-8 Thiophosphorsaeure- 
• 91338-87-3 Dithiophosphorsaeure- 
• 59502-86-2 (2,4-dibenzyl-2,5-dihydro-oxazol-2-yl)-methanol 
• 71151-16-1 2-chloromethyl-1,4-diphenyl-but-3-yn-2-ol 
• 4458-19-9 2-Chloromethyl-1-phenyl-but-3-yn-2-ol 

Relevant articles and documents

Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent "ene"-Reductases

α-Tertiary amines are a common motif in pharmaceutically important molecules but are challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin-dependent ‘ene'-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymatic catalysis for organic synthesis.

A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant

α-Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α-halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three-step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram-scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments. (Figure presented.).

Continuous flow generation and reactions of anhydrous diazomethane using a teflon AF-2400 tube-in-tube reactor

A continuous process for generation, separation, and reactions of anhydrous diazomethane in a tube-in-tube reactor was developed. The inner tube of the reactor is made of hydrophobic, gas-permeable Teflon AF-2400. The diazomethane is formed in the inner tube and then diffuses through the permeable membrane into the outer chamber and subsequently reacts in the solution carried within. This technique allows safe and scalable reactions with dry diazomethane to be performed on a laboratory scale.