79221-03-7

Upstream product

• 79220-94-3 1,4-diphenyl-1,3-dihydro-imidazole-2-thione 
• 591-50-4 iodobenzene 
• 670-95-1 4-Phenylimidazole 
• 75-11-6 diiodomethane 
• 23879-26-7 1-phenyl-4-dimethylamino-2-phenyl-1,3-diazabutadiene 
• 412311-09-2 2-benzylmercapto-1,4-diphenyl-1H-imidazole 
• 1111659-31-4 dimethyl 3a,5-diphenyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole-2,3-dicarboxylate 
• 108-86-1 bromobenzene 
• 1197040-29-1 phenyl isocyanate 
• 88333-03-3 Benzyl isocyanide 
• 6780-49-0 ethyl N-phenylformimidate 
• 3985-42-0 3-phenylbenzo[d]imidazo[5,1-b]thiazole 
• 7467-00-7 3-(2-oxo-2-phenylethyl)-1,3-benzothiazol-3-ium bromide 
• 95-16-9 1,3-Benzothiazole 

Downstream Products

• 1443769-36-5 2-(1,4-diphenyl-1H-imidazol-2-yl)-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanone 

Relevant academic research and scientific papers

Synthesis of N-Formyl-2-benzoyl Benzothiazolines, 2-Substituted Benzothiazoles, and Symmetrical Disulfides from N-Phenacylbenzothiazolium Bromides

An unusual aerobic hydrolysis-cascade reaction has been developed with N-phenacylbenzothiazolium bromides by treatment with organic and inorganic base. The corresponding N-formyl-2-benzoyl benzothiazoline and 2-substituted benzothiazole products were obta

A PEG/copper(i) halide cluster as an eco-friendly catalytic system for C-N bond formation

The catalytic activities of eight copper(i) halide clusters assembled from copper(i) halide and ferrocenyltelluroethers, 1-8, were investigated in C-N formation under various conditions. A catalytic procedure using poly(ethylene glycol) (PEG-400) as a gre

Tandem insertion-cyclization reaction of isocyanides in the synthesis of 1,4-diaryl-1H-imidazoles: Presence of N-arylformimidate intermediate

A straightforward and high-yielding synthesis of 1,4-diaryl-1H-imidazoles is reported. 1,4-Diaryl-1H-imidazoles have been difficult to access in ambient conditions, but our method utilizes two different facets of isocyanide reactivity to achieve it. The r

PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurologic

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurologic

C-N Coupling of nitrogen nucleophiles with aryl and heteroaryl bromides using aminoarenethiolato-copper(I) (pre-)catalyst

The activity of a library of 2-aminoarenethiolato-copper(I) (CuSAr) (pre-)catalyst was explored in the arylation reaction of amines and N-containing heterocycles with aryl and heteroaryl bromides, respectively. These CuSAr pre-catalysts are thermally stable, are soluble in common organic solvents and show good catalytic activities in these N-arylation reactions with catalyst loadings amounting to 2.5 mol %. The targeted C-N coupling products were obtained in moderate to good yields (40-97%) for a variety of substrates.

Thermal rearrangements of tetrahydroimidazo[1,5-b]isoxazole-2,3-dicarboxylates. Synthesis of 3H-imidazol-1-ium ylides and their silver derivatives

Isoxazolines 2 from the cycloaddition of imidazoline 3-oxides 1 with DMAD undergo rearrangement to 3,4-dihydro-2H-imidazol-1-ium-1-(1,2-bis-methoxycarbonyl-2-oxo-ethanides) 3, which spontaneously undergo elimination to give 3H-imidazol-1-ium-1-(1,2-bis-me

Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles

This paper details the copper-catalyzed N-arylation of π-excessive nitrogen heterocycles. The coupling of either aryl iodides or aryl bromides with common nitrogen heterocycles (pyrroles, pyrazoles, indazoles, imidazoles, and triazoles) was successfully performed in good yield with catalysts derived from diamine ligands and CuI. General conditions were found that tolerate functional groups such as aldehydes, ketones, alcohols, primary amines, and nitriles on the aryl halide or heterocycle. Hindered aryl halides or heterocycles were also found to be suitable substrates using the conditions reported herein.

Unusual methylene transfer in reactions of Simmons-Smith reagent with 1,3-diazabuta-1,3-dienes: Synthesis of functionalised imidazole derivatives

The reactions of Simmons-Smith reagent with 1-aryl-2-phenyl-4-methylthio-4-secondary amino 1,3-diazabuta-1,3-dienes 1 underwent an unusual 1,4-methylene transfer resulting in the formation of 1-aryl-2-phenyl-4-secondary amino imidazoles 4. Whereas, its re

An efficient copper-catalyzed coupling of aryl halides with imidazoles

Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)2 · benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 °C. Addition of 1,10-phenanthroline (phen) and trans, trans- dibenzylide