28269-82-1Relevant articles and documents
Synthesis and characterization of isothiobiurets of N-glucosylated compounds and their antimicrobial activities
Sarap, Ashish G.,Deshmukh, Shirish P.
, p. 1015 - 1018 (2013/09/23)
A series of several 1-aryl-5-tetra-O-acetyl-β-glucopyranosyl-2-S- benzyl-2-isothiobiurets have been prepared by the interaction of aryl S-benzylisothiocarbamides and tetra-O-acetyl-β-glucopyranosyl isocyanate. The required aryl S-benzylisothiocarbamides was prepared by S-benzylation of different thioureas and tetra-O-acetyl-β-D-glucopyranosyl isocyanate was prepared by interaction of tetra-O-acetyl-α-D-glucopyranosyl bromide and lead cyanate. The structures of the newly synthesized compounds have been established on the basis of usual chemical transformations and IR, 1H NMR and Mass spectral studies. All the synthesized compounds have been evaluated for their in vitro antibacterial and antifungal activity against different bacteria and fungi by agar diffusion method.
Synthesis and antiinflammatory properties of N-substituted guanidines
Pathak, Santosh,Singh, Dhananjay,Singh, Ved Prakash
experimental part, p. 2483 - 2486 (2012/01/05)
Various N[(p-substituted/unsubstituted)phenyl), (substituted thiazol-2-yl/oxazol-2-yl/naphthothiazol-2-yl)],N'-[N''',N'''-dimethyl/ diethylaminoacetyl],N''-phenyl guanidines were prepared from corresponding N-substituted thiocarbamides and were evaluated for their antiinflammatory activity. All the substituted guanidines (100 mg/Kg) provided 1-79 % protection against carrageenin induced edema in rats. Phenyl butazone (100 mg/Kg) was used as a standard drug for comparative evaluation and showed greater antiinflammatory activity. The results suggest that the presence of methoxy group on phenyl nuclei at para position enhances antiinflammatory activity. The increase in chain length on alkyl group of N (R)2 skeleton also cause some enhancement in activity. Among heterocyclic molecules maximum level of antiinflammatory activity is shown by oxazol-2-yl substituted guanidines.
Synthesis of N-galactosylated isodithiobiurets
Mahalle, Prashant R.,Deshmukh, Shirish P.
experimental part, p. 742 - 745 (2009/12/05)
Several 1-aryl-5-tetra-O-acetyl-β-D-galactosyl-2-S-benzyl-2,4- isodithiobiurets have been prepared by the interaction of aryl-S-benzyl isothiocarbamides and tetra-O-acetyl-β-D-galactosyl isothiocyanate. The structures of the newly synthesized compounds have been established on the basis of usual chemical transformations and IR, NMR and Mass spectral studies.
Bond-Switch Rearrangement of 3-Oxo-Δ4-1,2,4-thiadiazolin-5-yl Ureas
L'abbe, Gerrit,Albrecht, Ernestine,Toppet, Suzanne
, p. 1619 - 1624 (2007/10/02)
5-Amino-3-oxo-Δ4-1,2,4-thiadiazolines 5a,b react with isocyanates to yield 1,2,4-thiadiazolidine derivatives 9a-d via bond switching of the corresponding isomers 7.The same type of products 9e-m was obtained by treatment of 5-amino-1,2,3,4-thia
2-Imidazolines. IV (1). 1-Aryl-2-alkylthio-4,5-diamino-4,5-dihydroimidazoles. Synthesis and Properties
Meola, Stefania,Rivera, Elisabetta,Stradi, Riccardo,Gioia, Bruno
, p. 1041 - 1044 (2007/10/02)
1,2-Diimmonium salts (1) react with S-substituted isothioureas (3) yielding 2-alkylthio-4,5-diamino-4,5-dihydroimidazoles (4), which under mild pyrolytic conditions afforded 2-alkylthio-5-aminoimidazoles (7).Imidazolines (4) and imidazoles (7) were easily
