112450-34-7

Upstream product

• 79225-55-1 3-oxo-5,6-diphenyl-2,3-dihydro-pyridazine-4-carbonitrile 
• 94011-79-7 3-chloro-5,6-diphenylpyridazine-4-carbonitrile 
• 7357-70-2 Cyanothioacetamide 
• 5344-88-7 benzil monohydrazone 
• 134129-60-5 (Z)-2-Cyano-4-hydrazono-3,4-diphenyl-but-2-enethioic acid amide 
• 134-81-6 benzil 
• 134129-61-6 3,4-diphenyl-5-cyano-6-(ethoxycarbonylmethylthio)pyridazine 
• 134129-59-2 (Z)-2-Cyano-4-oxo-3,4-diphenyl-but-2-enethioic acid amide 
• 79225-55-1 4-cyano-5,6-diphenylpyridazin-3(2H)-one 

Downstream Products

• 112450-31-4 4-(2,3-dihydro-5,6-diphenyl-3-thiopyridazinyl) diphenylcarbinol 
• 107042-54-6 5-amino-3,4-diphenyl-7H-pyrazolo-<3,4-c>-pyridazine 
• 128462-40-8 ethyl 5-amino-3,4-diphenylfuro<2,3-c>pyridazine-6-carboxylate 
• 128462-42-0 ethyl 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbohydrazide 
• 135127-78-5 5-amino-3,4-diphenylthieno<2,3-c>pyridazine-6-carboxamide 
• 183868-01-1 3-Cyanomethylthio-4-cyano-5,6-diphenylpyridazine 
• 134129-62-7 3,4-diphenyl-5-cyano-6-(carboxyamidomethylthio)pyridazine 
• 178681-99-7 5-amino-3,4-diphenylthieno[2,3-c]pyridazine 6-carbonitrile 
• 299464-86-1 5-amino-3,4-diphenyl-6-(N-phenyl)carbamoylthieno[2,3-c]pyridazine 
• 299464-88-3 5-amino-3,4-diphenyl-thieno[2,3-c]pyridazine-6-carboxylic acid (4-methoxy-phenyl)-amide 
• 872057-84-6 3-(1H-benzoimidazol-2-ylmethylsulfanyl)-5,6-diphenyl-pyridazine-4-carbonitrile 
• 183868-03-3 (8-Chloro-3,4-diphenyl-pyrimido[4',5':4,5]thieno[2,3-c]pyridazin-6-yl)-dimethyl-amine 
• 183382-28-7 8-Chloro-3,4,6-triphenyl-pyrimido[4',5':4,5]thieno[2,3-c]pyridazine 

Relevant academic research and scientific papers

Pyridazine derivatives and related compounds, part 28.1 pyridazinesulfonamides: Synthesis and antimicrobial activity

The reaction of 3-chloropyridazine 1 with N -(un)Substituted 4-aminosulfonamides 3 gave the 3-substituted aminopyridazines 4. Also In addition, pyridazine-3-sulfonamides 7 were prepared from the reaction of pyridazine-3-sulfonylchloride 6 with different amines. All of these derivatives have been characterized by analytical and spectroscopic studies, and also were tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

Synthesis of Pyrimido[4′,5′:4,5]thieno[2,3-c]-pyridazine Derivatives

Convenient syntheses of 3,4-diphenyl-8-oxo-6-substituted-5,6,7,8-tetrahydropyrimido[4′, 5′:4,5]thieno[2,3-c]pyridazines (4a-g), 3,4-diphenyl-8-oxo-6-substituted-7,8-dihydropyrimido[4′,5′: 4,5]thieno[2,3-c]pyridazines (5a-g), 8-chloro-3,4-diphenyl-6-substituted-pyrimido[4′,5′:4,5]thieno [2,3-c]pyridazines (6a-g), and 3,4,6-triphenyl-8-substituted-pyrimido[4′,5′:4,5]thieno[2,3-c] pyridazines (7a-f) from 4-cyano-5,6-diphenylpyridazine-3(2H)-thione (1) via 5-amino-3,4-diphenyl-thieno[2,3-c]pyridazine-6-carboxamide (3) are reported.

BENZIL IN HETEROCYCLIC SYNTHESIS: SYNTHESIS AND REACTIONS OF 3,4-DIPHENYL-5-CYANO-PYRIDAZINE-6-THIONE

3,4-Diphenyl-5-cyanopyridazine-6-thione (7) is prepared via three routes either by the reaction of benzil hydrazone (1) and cyanothioacetamide (2) or by the reaction of benzil (3) with cyanothioacetamide to give (4) which reacts with hydrazine hydrate to give the intermediate (5) that cyclised to (7) by boiling with glacial acetic acid or by the action of P2S5 on 3,4-diphenyl-5-cyanopyridazin-6-one (6).Methylation of the SH group in (7) afforded (8) while its reaction with ethyl bromoacetate gave the pyridazine derivative (9).Treatment of (8) and (9) with hydrazine hydrate produced directly the pyrazolopyridazine derivative (10).Treatment of (9) with NH3/EtOH afforded the amidic derivative (11) while its treatment with dil.HCl gave 3,4-diphenyl-5-cyanopyridazin-6-one (6).Treatment of (9) with NH3/heat then acidification gave carboxylic derivative (12).Treatment of (9) with p-chloroaniline and p-toluidine gave p-chloroanilino and toluidino derivatives (13a,b).Keywords: Pyridazine-6-thiones; synthesis, reactions IR and 1H-NMR.