79278-88-9

Basic information

• Product Name: N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride
• Synonyms: N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride
• CAS NO: 79278-88-9
• Molecular Weight: 378.966
• Mol File: 79278-88-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride(79278-88-9)
• EPA Substance Registry System: N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride(79278-88-9)

Safety Data

• Hazardous Substances Data: 79278-88-9(Hazardous Substances Data)

Upstream product

• 40412-06-4 2-(2-thienyl)ethyl tosylate 
• 1609-66-1 Norfentanyl 
• 1165-22-6 thiofentanyl 
• 92065-14-0 N-[2-(2-thienyl)ethyl]-4-piperidinone 
• 61380-07-2 2-(thiophen-2-yl)ethyl methanesulfonate 
• 62-53-3 aniline 
• 1474-02-8 N-(1-benzyl-4-piperidinyl)-N-phenylpropionamide 
• 1155-56-2 1-benzyl-N-phenylpiperidin-4-amine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 5402-55-1 2-thiophenethanol 

Relevant articles and documents

An efficient, optimized synthesis of fentanyl and related analogs

The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy produced a panel of four fentanyls in excellent yields (73-78%) along with their more commonly encountered hydrochloride and citric acid salts. The following strategy offers the opportunity for the gram-scale, efficient production of this interesting class of opioid alkaloids.