87939-25-1

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 79286-73-0 1-ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-1,8-naphthyridine-3-carboxylic acid 
• 87939-09-1 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 84233-60-3 ethyl 7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 82671-13-4 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 87938-98-5 C₁₉H₂₃N₆O₄⁽¹⁺⁾*F₆P^(1-) 
• 87939-04-6 7-(4-Acetyl-piperazin-1-yl)-1-ethyl-6-nitro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 87938-96-3 7-(4-Acetyl-piperazin-1-yl)-6-amino-1-ethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 54132-41-1 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 56654-05-8 ethyl 7-chloro-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 

Relevant academic research and scientific papers

Pyridonecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent

The title compounds having nitro, amino, cyano, chloro, or fluoro as the C-6 substituent were prepared. Introduction of the chloro and cyano groups at C-6 was accomplished by the Sandmeyer reaction of 6-amino-1,8-naphthyridine derivatives via their 6-diaz